Capillary electrophoresis at the omics level: Towards systems biology

Emerging systems biology aims at integrating the enormous amount of existing omics data in order to better understand their functional relationships at a whole systems level. These huge datasets can be obtained through advances in high‐throughput, sensitive, precise, and accurate analytical instrume...

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Bibliographic Details
Published in:Electrophoresis 2006-01, Vol.27 (1), p.97-110
Main Authors: Babu C. V., Suresh, Song, Eun Joo, Babar, Sheikh Md. Enayetul, Wi, Mun Hyung, Yoo, Young Sook
Format: Article
Language:English
Subjects:
Animals
Capillary electrophoresis
Electrophoresis, Capillary
Genomics - methods
Humans
Omics
Pharmacology - methods
Proteomics - methods
Review
Sequence Analysis, DNA - methods
Systems biology
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Summary:Emerging systems biology aims at integrating the enormous amount of existing omics data in order to better understand their functional relationships at a whole systems level. These huge datasets can be obtained through advances in high‐throughput, sensitive, precise, and accurate analytical instrumentation and technological innovation. Separation sciences play an important role in revealing biological processes at various omic levels. From the perspective of systems biology, CE is a strong candidate for high‐throughput, sensitive data generation which is capable of tackling the challenges in acquiring qualitative and quantitative knowledge through a system‐level study. This review focuses on the applicability of CE to systems‐based analytical data at the genomic, transcriptomic, proteomic, and metabolomic levels.
ISSN:0173-0835
1522-2683
DOI:10.1002/elps.200500511