Intellectual asymmetry and genetic liability in first-degree relatives of probands with schizophrenia

Intellectual asymmetry with superiority of verbal skills to spatial skills frequently characterises patients with schizophrenia, but it is unclear whether this pattern also reflects genetic susceptibility to the disorder. We examined the association of a continuous measure of genetic liability to sc...

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Bibliographic Details
Published in:British journal of psychiatry 2006-02, Vol.188 (2), p.186-187
Main Authors: Kravariti, Eugenia, Toulopoulou, Timothea, Mapua-Filbey, Francesca, Schulze, Katja, Walshe, Muriel, Sham, Pak, Murray, Robin M., McDonald, Colm
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Family Health
Female
Genetic Predisposition to Disease
Genetic susceptibility
Humans
Intellectual ability
Intelligence
Intelligence Tests
Male
Middle Aged
Phenotype
Schizophrenia
Schizophrenia - genetics
Schizophrenic Psychology
Short Reports
Verbal Behavior
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Summary:Intellectual asymmetry with superiority of verbal skills to spatial skills frequently characterises patients with schizophrenia, but it is unclear whether this pattern also reflects genetic susceptibility to the disorder. We examined the association of a continuous measure of genetic liability to schizophrenia with Verbal-Spatial Contrast IQ (an index of intellectual asymmetry) in 108 first-degree relatives without psychosis of probands with schizophrenia. Higher genetic liability was significantly associated with greater intellectual asymmetry in favour of verbal skills. Intellectual asymmetry with a relative superiority of verbal skills to spatial skills represents a putative endophenotype of schizophrenia.
ISSN:0007-1250
1472-1465
DOI:10.1192/bjp.bp.104.008177