Oxidative stress in childhood type 1 diabetes: Results from a study covering the first 20 years of evolution

This study aimed to further analyse the potential role of oxidative stress in children and adolescents with type 1 diabetes at clinical onset, during disease progression and when early microvascular complications ( + DC) appeared. Compared with age-matched controls, diabetic patients had greater oxi...

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Bibliographic Details
Published in:Free radical research 2007-01, Vol.41 (8), p.919-928
Main Authors: Martín-Gallán, Pilar, Carrascosa, Antonio, Gussinyé, Miguel, Domínguez, Carmen
Format: Article
Language:English
Subjects:
Adolescent
Antioxidant enzymes
Child
Cholesterol - blood
Deoxyadenosines - analysis
Diabetes Mellitus, Type 1 - etiology
Disease Progression
Erythrocytes - chemistry
Erythrocytes - enzymology
Female
glutathione
Humans
lipid peroxidation
Male
malondialdehyde
Malondialdehyde - blood
microvascular complications
Oxidative Stress
Oxidoreductases - analysis
protein oxidation
reactive oxygen species
Triglycerides - blood
type 1 diabetes mellitus
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Summary:This study aimed to further analyse the potential role of oxidative stress in children and adolescents with type 1 diabetes at clinical onset, during disease progression and when early microvascular complications ( + DC) appeared. Compared with age-matched controls, diabetic patients had greater oxidative damage to lipids, proteins and DNA demonstrated by analysis of plasma and erythrocyte malondialdehyde, carbonyl proteins and leukocyte 8-hydroxy-deoxyguanosine, all of which were significantly raised at onset, decreased during the first 1.5 years of evolution and rose progressively thereafter. Plasma lipid levels were significantly associated with lipid and protein oxidation products. Erythrocyte glutathione and glutathione-peroxidase activity were significantly decreased with the lowest values at onset and in + DC sub-groups. Insulin therapy in the first year improved metabolic and oxidant-antioxidant status and, consequently, hyperglycaemia-derived biomolecular oxidative damage. Diabetes-associated hyperlipidaemia is related to lipid and protein oxidation, thereby supporting the concept of glucotoxicity and lipotoxicity being inter-related. The overall increase in lipid, protein and DNA oxidative damage in diabetic patients with microangiopathy could be pathogenetically relevant in the early development of diabetes-related complications.
ISSN:1071-5762
1029-2470
DOI:10.1080/10715760701435228