Kidney Dysfunction and Sudden Cardiac Death Among Women With Coronary Heart Disease

• Published in: Hypertension (Dallas, Tex. 1979) Tex. 1979), 2008-06, Vol.51 (6), p.1578-1582
• Main Authors: Deo, Rajat, Lin, Feng, Vittinghoff, Eric, Tseng, Zian H, Hulley, Stephen B, Shlipak, Michael G
• Format: Article
• Language: English
• Subjects: Aged; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Coronary Disease - mortality; Coronary Disease - prevention & control; Coronary heart disease; Death, Sudden, Cardiac - epidemiology; Estrogen Replacement Therapy; Estrogens, Conjugated (USP) - administration & dosage; Female; Follow-Up Studies; Glomerular Filtration Rate; Heart; Humans; Incidence; Kidney Diseases - mortality; Medical sciences; Medroxyprogesterone Acetate - administration & dosage; Middle Aged; Multivariate Analysis; Postmenopause; Predictive Value of Tests; Risk Factors
• ISSN: 0194-911X; 1524-4563
• DOI: 10.1161/HYPERTENSIONAHA.107.103804

We evaluated the association between kidney dysfunction and sudden cardiac death risk among ambulatory women with coronary heart disease. The Heart and Estrogen Replacement Study evaluated the effects of hormone treatment on cardiovascular events among 2763 postmenopausal women with coronary heart disease. Kidney dysfunction was categorized by estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease equation. Multivariate proportional hazards models were used to adjust for cardiovascular risk factors, congestive heart failure, and myocardial infarction. At baseline, 37% (n=1027) had an eGFR of >60 mL/min, 54% (n=1503) had an eGFR of 40 to 60 mL/min, and 8% (n=230) had an eGFR of 60; 0.6% per year with an eGFR between 40 and 60; and 1.7% per year with an eGFR