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Kidney Dysfunction and Sudden Cardiac Death Among Women With Coronary Heart Disease
We evaluated the association between kidney dysfunction and sudden cardiac death risk among ambulatory women with coronary heart disease. The Heart and Estrogen Replacement Study evaluated the effects of hormone treatment on cardiovascular events among 2763 postmenopausal women with coronary heart d...
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| Published in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 2008-06, Vol.51 (6), p.1578-1582 |
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| container_end_page | 1582 |
| container_issue | 6 |
| container_start_page | 1578 |
| container_title | Hypertension (Dallas, Tex. 1979) |
| container_volume | 51 |
| creator | Deo, Rajat Lin, Feng Vittinghoff, Eric Tseng, Zian H Hulley, Stephen B Shlipak, Michael G |
| description | We evaluated the association between kidney dysfunction and sudden cardiac death risk among ambulatory women with coronary heart disease. The Heart and Estrogen Replacement Study evaluated the effects of hormone treatment on cardiovascular events among 2763 postmenopausal women with coronary heart disease. Kidney dysfunction was categorized by estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease equation. Multivariate proportional hazards models were used to adjust for cardiovascular risk factors, congestive heart failure, and myocardial infarction. At baseline, 37% (n=1027) had an eGFR of >60 mL/min, 54% (n=1503) had an eGFR of 40 to 60 mL/min, and 8% (n=230) had an eGFR of 60; 0.6% per year with an eGFR between 40 and 60; and 1.7% per year with an eGFR |
| doi_str_mv | 10.1161/HYPERTENSIONAHA.107.103804 |
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The Heart and Estrogen Replacement Study evaluated the effects of hormone treatment on cardiovascular events among 2763 postmenopausal women with coronary heart disease. Kidney dysfunction was categorized by estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease equation. Multivariate proportional hazards models were used to adjust for cardiovascular risk factors, congestive heart failure, and myocardial infarction. At baseline, 37% (n=1027) had an eGFR of >60 mL/min, 54% (n=1503) had an eGFR of 40 to 60 mL/min, and 8% (n=230) had an eGFR of <40 mL/min. During the 6.8-year follow-up period, there were 136 adjudicated sudden cardiac deaths. The rate of sudden cardiac death was higher in those with lower kidney function (0.5% per year among those with an eGFR >60; 0.6% per year with an eGFR between 40 and 60; and 1.7% per year with an eGFR <40 mL/min; P for trend <0.001). After multivariate analysis with baseline risk factors, eGFR at 40 to 60 mL/min was not a significant predictor, but eGFR at <40 mL/min remained strongly associated with sudden cardiac death (hazard ratio3.2; 95% CI1.9 to 5.3); adjustment for incident congestive heart failure and myocardial infarction during follow-up diminished this association (hazard ratio2.3; 95% CI1.3 to 3.9), suggesting that congestive heart failure and myocardial infarction mediated only part of the association between kidney dysfunction and sudden cardiac death. Advanced kidney dysfunction is an independent predictor of sudden cardiac death among women with coronary heart disease.</description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/HYPERTENSIONAHA.107.103804</identifier><identifier>PMID: 18391103</identifier><identifier>CODEN: HPRTDN</identifier><language>eng</language><publisher>Philadelphia, PA: American Heart Association, Inc</publisher><subject>Aged ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Coronary Disease - mortality ; Coronary Disease - prevention & control ; Coronary heart disease ; Death, Sudden, Cardiac - epidemiology ; Estrogen Replacement Therapy ; Estrogens, Conjugated (USP) - administration & dosage ; Female ; Follow-Up Studies ; Glomerular Filtration Rate ; Heart ; Humans ; Incidence ; Kidney Diseases - mortality ; Medical sciences ; Medroxyprogesterone Acetate - administration & dosage ; Middle Aged ; Multivariate Analysis ; Postmenopause ; Predictive Value of Tests ; Risk Factors</subject><ispartof>Hypertension (Dallas, Tex. 1979), 2008-06, Vol.51 (6), p.1578-1582</ispartof><rights>2008 American Heart Association, Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5179-98f76d314264c2809eb96fd5418920ea2fca4613f5607f3a58005bc579af3be53</citedby><cites>FETCH-LOGICAL-c5179-98f76d314264c2809eb96fd5418920ea2fca4613f5607f3a58005bc579af3be53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20393122$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18391103$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deo, Rajat</creatorcontrib><creatorcontrib>Lin, Feng</creatorcontrib><creatorcontrib>Vittinghoff, Eric</creatorcontrib><creatorcontrib>Tseng, Zian H</creatorcontrib><creatorcontrib>Hulley, Stephen B</creatorcontrib><creatorcontrib>Shlipak, Michael G</creatorcontrib><title>Kidney Dysfunction and Sudden Cardiac Death Among Women With Coronary Heart Disease</title><title>Hypertension (Dallas, Tex. 1979)</title><addtitle>Hypertension</addtitle><description>We evaluated the association between kidney dysfunction and sudden cardiac death risk among ambulatory women with coronary heart disease. The Heart and Estrogen Replacement Study evaluated the effects of hormone treatment on cardiovascular events among 2763 postmenopausal women with coronary heart disease. Kidney dysfunction was categorized by estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease equation. Multivariate proportional hazards models were used to adjust for cardiovascular risk factors, congestive heart failure, and myocardial infarction. At baseline, 37% (n=1027) had an eGFR of >60 mL/min, 54% (n=1503) had an eGFR of 40 to 60 mL/min, and 8% (n=230) had an eGFR of <40 mL/min. During the 6.8-year follow-up period, there were 136 adjudicated sudden cardiac deaths. The rate of sudden cardiac death was higher in those with lower kidney function (0.5% per year among those with an eGFR >60; 0.6% per year with an eGFR between 40 and 60; and 1.7% per year with an eGFR <40 mL/min; P for trend <0.001). After multivariate analysis with baseline risk factors, eGFR at 40 to 60 mL/min was not a significant predictor, but eGFR at <40 mL/min remained strongly associated with sudden cardiac death (hazard ratio3.2; 95% CI1.9 to 5.3); adjustment for incident congestive heart failure and myocardial infarction during follow-up diminished this association (hazard ratio2.3; 95% CI1.3 to 3.9), suggesting that congestive heart failure and myocardial infarction mediated only part of the association between kidney dysfunction and sudden cardiac death. Advanced kidney dysfunction is an independent predictor of sudden cardiac death among women with coronary heart disease.</description><subject>Aged</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Coronary Disease - mortality</subject><subject>Coronary Disease - prevention & control</subject><subject>Coronary heart disease</subject><subject>Death, Sudden, Cardiac - epidemiology</subject><subject>Estrogen Replacement Therapy</subject><subject>Estrogens, Conjugated (USP) - administration & dosage</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glomerular Filtration Rate</subject><subject>Heart</subject><subject>Humans</subject><subject>Incidence</subject><subject>Kidney Diseases - mortality</subject><subject>Medical sciences</subject><subject>Medroxyprogesterone Acetate - administration & dosage</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Postmenopause</subject><subject>Predictive Value of Tests</subject><subject>Risk Factors</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqFkF1rFDEUhoModq3-BQmC3k09-Z54t-yu3WJpxa1Ur4ZsJnFHZ5KazFD23zdlFwVvDBxC3jznhDwIvSFwRogk79ffP6--3KyuNhfXV_P1_IyAKsVq4E_QjAjKKy4ke4pmQDSvNCHfTtCLnH8CEM65eo5OSM1KDGyGNp-6Nrg9Xu6zn4IduxiwCS3eTG3rAl6Y1HbG4qUz4w7Phxh-4Ns4lJvbrgSLmGIwaY_XzqQRL7vsTHYv0TNv-uxeHfdT9PXj6maxri6vzy8W88vKCqJ0pWuvZMsIp5JbWoN2Wy19KzipNQVnqLeGS8K8kKA8M6IGEFsrlDaebZ1gp-jdYe5dir8nl8dm6LJ1fW-Ci1NuFCjGGZf_BYlWlDP5OPHDAbQp5pycb-5SN5QPNgSaR_fNP-5LrpqD-9L8-vjKtB1c-7f1KLsAb4-Aydb0Pplgu_yHo8A0I5QWjh-4-9iPLuVf_XTvUrNzph93DZRVlNUVBahBllNVimr2AGAcnKc</recordid><startdate>200806</startdate><enddate>200806</enddate><creator>Deo, Rajat</creator><creator>Lin, Feng</creator><creator>Vittinghoff, Eric</creator><creator>Tseng, Zian H</creator><creator>Hulley, Stephen B</creator><creator>Shlipak, Michael G</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>200806</creationdate><title>Kidney Dysfunction and Sudden Cardiac Death Among Women With Coronary Heart Disease</title><author>Deo, Rajat ; Lin, Feng ; Vittinghoff, Eric ; Tseng, Zian H ; Hulley, Stephen B ; Shlipak, Michael G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5179-98f76d314264c2809eb96fd5418920ea2fca4613f5607f3a58005bc579af3be53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Coronary Disease - mortality</topic><topic>Coronary Disease - prevention & control</topic><topic>Coronary heart disease</topic><topic>Death, Sudden, Cardiac - epidemiology</topic><topic>Estrogen Replacement Therapy</topic><topic>Estrogens, Conjugated (USP) - administration & dosage</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glomerular Filtration Rate</topic><topic>Heart</topic><topic>Humans</topic><topic>Incidence</topic><topic>Kidney Diseases - mortality</topic><topic>Medical sciences</topic><topic>Medroxyprogesterone Acetate - administration & dosage</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Postmenopause</topic><topic>Predictive Value of Tests</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Deo, Rajat</creatorcontrib><creatorcontrib>Lin, Feng</creatorcontrib><creatorcontrib>Vittinghoff, Eric</creatorcontrib><creatorcontrib>Tseng, Zian H</creatorcontrib><creatorcontrib>Hulley, Stephen B</creatorcontrib><creatorcontrib>Shlipak, Michael G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deo, Rajat</au><au>Lin, Feng</au><au>Vittinghoff, Eric</au><au>Tseng, Zian H</au><au>Hulley, Stephen B</au><au>Shlipak, Michael G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kidney Dysfunction and Sudden Cardiac Death Among Women With Coronary Heart Disease</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>2008-06</date><risdate>2008</risdate><volume>51</volume><issue>6</issue><spage>1578</spage><epage>1582</epage><pages>1578-1582</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><coden>HPRTDN</coden><abstract>We evaluated the association between kidney dysfunction and sudden cardiac death risk among ambulatory women with coronary heart disease. The Heart and Estrogen Replacement Study evaluated the effects of hormone treatment on cardiovascular events among 2763 postmenopausal women with coronary heart disease. Kidney dysfunction was categorized by estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease equation. Multivariate proportional hazards models were used to adjust for cardiovascular risk factors, congestive heart failure, and myocardial infarction. At baseline, 37% (n=1027) had an eGFR of >60 mL/min, 54% (n=1503) had an eGFR of 40 to 60 mL/min, and 8% (n=230) had an eGFR of <40 mL/min. During the 6.8-year follow-up period, there were 136 adjudicated sudden cardiac deaths. The rate of sudden cardiac death was higher in those with lower kidney function (0.5% per year among those with an eGFR >60; 0.6% per year with an eGFR between 40 and 60; and 1.7% per year with an eGFR <40 mL/min; P for trend <0.001). After multivariate analysis with baseline risk factors, eGFR at 40 to 60 mL/min was not a significant predictor, but eGFR at <40 mL/min remained strongly associated with sudden cardiac death (hazard ratio3.2; 95% CI1.9 to 5.3); adjustment for incident congestive heart failure and myocardial infarction during follow-up diminished this association (hazard ratio2.3; 95% CI1.3 to 3.9), suggesting that congestive heart failure and myocardial infarction mediated only part of the association between kidney dysfunction and sudden cardiac death. Advanced kidney dysfunction is an independent predictor of sudden cardiac death among women with coronary heart disease.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>18391103</pmid><doi>10.1161/HYPERTENSIONAHA.107.103804</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Hypertension (Dallas, Tex. 1979), 2008-06, Vol.51 (6), p.1578-1582 |
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| subjects | Aged Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Coronary Disease - mortality Coronary Disease - prevention & control Coronary heart disease Death, Sudden, Cardiac - epidemiology Estrogen Replacement Therapy Estrogens, Conjugated (USP) - administration & dosage Female Follow-Up Studies Glomerular Filtration Rate Heart Humans Incidence Kidney Diseases - mortality Medical sciences Medroxyprogesterone Acetate - administration & dosage Middle Aged Multivariate Analysis Postmenopause Predictive Value of Tests Risk Factors |
| title | Kidney Dysfunction and Sudden Cardiac Death Among Women With Coronary Heart Disease |
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