Abrupt changes in fibrillatory wave characteristics at the termination of paroxysmal atrial fibrillation in humans

Aims We investigated the process of spontaneous termination of atrial fibrillation (AF) to determine its time course from the surface ECG. Methods and results We studied fibrillatory waves in Holter recordings of paroxysmal and sustained AF. Following QRS-T cancellation dominant frequencies (DFs) we...

Full description

Saved in:
Bibliographic Details
Published in:Europace (London, England) England), 2007-07, Vol.9 (7), p.466-470
Main Authors: Petrutiu, Simona, Sahakian, Alan V., Swiryn, Steven
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Atrial Fibrillation - physiopathology
Electrocardiography, Ambulatory
Female
Fourier Analysis
Humans
Male
Middle Aged
Predictive Value of Tests
Signal Processing, Computer-Assisted
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c3796-2ae81da7eacb7fcbd90fa5f4b05220543b6a32d80dc619c807116279441a61aa3
cites cdi_FETCH-LOGICAL-c3796-2ae81da7eacb7fcbd90fa5f4b05220543b6a32d80dc619c807116279441a61aa3
container_end_page 470
container_issue 7
container_start_page 466
container_title Europace (London, England)
container_volume 9
creator Petrutiu, Simona
Sahakian, Alan V.
Swiryn, Steven
description Aims We investigated the process of spontaneous termination of atrial fibrillation (AF) to determine its time course from the surface ECG. Methods and results We studied fibrillatory waves in Holter recordings of paroxysmal and sustained AF. Following QRS-T cancellation dominant frequencies (DFs) were computed and the relationship of DF to termination was scrutinized. For 57 episodes of paroxysmal AF (PAF) in 24 patients, DF ranged from 4.4 to 6.5 Hz (5.2 ± 0.4 Hz) compared to 5.8 to 7.4 Hz (6.6 ± 0.6 Hz) for sustained AF recordings. Comparison of the atrial frequency of the ultimate to the penultimate second demonstrated a drop in frequency in 51 of 57 episodes, P < 0.00001. No comparable change was seen at longer time periods. Moments of comparably low frequency without termination were only occasionally seen in patients with PAF but not in patients with sustained AF. Conclusion Low frequency fibrillation was found to be much more likely to terminate. Frequency changes preceding spontaneous termination were abrupt, in contrast to the gradual frequency drop reported with drug-induced termination. The analysis of fibrillatory wave characteristics and their change over time might be used to target specific moments for pacing therapy in patients with AF.
doi_str_mv 10.1093/europace/eum096
format article
fullrecord <record><control><sourceid>proquest_TOX</sourceid><recordid>TN_cdi_proquest_miscellaneous_70738057</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/europace/eum096</oup_id><sourcerecordid>70738057</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3796-2ae81da7eacb7fcbd90fa5f4b05220543b6a32d80dc619c807116279441a61aa3</originalsourceid><addsrcrecordid>eNqFkU1LxDAQhoMoun6cvUnw4EGoO0napjku4hcIXvRcpmnqZtk2NWnV_fdm2VXBi6cZJs88DHkJOWVwxUCJqRm961Gb2LSg8h0yYZngCQfFd2MPSiUZ4-qAHIawAADJVbZPDpjMUshzMSF-VvmxH6ieY_dqArUdbWzl7XKJg_Mr-oHvZv3oUQ_G2zBYHSgOdJgbGget7XCwrqOuoT1697kKLS4j4G0sP6Y1Ec3zscUuHJO9BpfBnGzrEXm5vXm-vk8en-4ermePiRZS5QlHU7AapUFdyUZXtYIGsyatIOMcslRUOQpeF1DrnCldgGQs51KlKcOcIYojcrHx9t69jSYMZWuDNvGezrgxlBKkKCCTETz_Ay7c6Lt4W8lUIYDJYg1NN5D2LgRvmrL3tkW_KhmU6yzK7yzKTRZx42yrHavW1L_89vMjcLkB3Nj_a_sCjaiYzg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>198301787</pqid></control><display><type>article</type><title>Abrupt changes in fibrillatory wave characteristics at the termination of paroxysmal atrial fibrillation in humans</title><source>Oxford Open</source><creator>Petrutiu, Simona ; Sahakian, Alan V. ; Swiryn, Steven</creator><creatorcontrib>Petrutiu, Simona ; Sahakian, Alan V. ; Swiryn, Steven</creatorcontrib><description>Aims We investigated the process of spontaneous termination of atrial fibrillation (AF) to determine its time course from the surface ECG. Methods and results We studied fibrillatory waves in Holter recordings of paroxysmal and sustained AF. Following QRS-T cancellation dominant frequencies (DFs) were computed and the relationship of DF to termination was scrutinized. For 57 episodes of paroxysmal AF (PAF) in 24 patients, DF ranged from 4.4 to 6.5 Hz (5.2 ± 0.4 Hz) compared to 5.8 to 7.4 Hz (6.6 ± 0.6 Hz) for sustained AF recordings. Comparison of the atrial frequency of the ultimate to the penultimate second demonstrated a drop in frequency in 51 of 57 episodes, P &lt; 0.00001. No comparable change was seen at longer time periods. Moments of comparably low frequency without termination were only occasionally seen in patients with PAF but not in patients with sustained AF. Conclusion Low frequency fibrillation was found to be much more likely to terminate. Frequency changes preceding spontaneous termination were abrupt, in contrast to the gradual frequency drop reported with drug-induced termination. The analysis of fibrillatory wave characteristics and their change over time might be used to target specific moments for pacing therapy in patients with AF.</description><identifier>ISSN: 1099-5129</identifier><identifier>EISSN: 1532-2092</identifier><identifier>DOI: 10.1093/europace/eum096</identifier><identifier>PMID: 17540663</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Atrial Fibrillation - physiopathology ; Electrocardiography, Ambulatory ; Female ; Fourier Analysis ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Signal Processing, Computer-Assisted</subject><ispartof>Europace (London, England), 2007-07, Vol.9 (7), p.466-470</ispartof><rights>The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org 2007</rights><rights>Copyright Oxford Publishing Limited(England) Jul 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3796-2ae81da7eacb7fcbd90fa5f4b05220543b6a32d80dc619c807116279441a61aa3</citedby><cites>FETCH-LOGICAL-c3796-2ae81da7eacb7fcbd90fa5f4b05220543b6a32d80dc619c807116279441a61aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1598,27903,27904</link.rule.ids><linktorsrc>$$Uhttps://dx.doi.org/10.1093/europace/eum096$$EView_record_in_Oxford_University_Press$$FView_record_in_$$GOxford_University_Press</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17540663$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Petrutiu, Simona</creatorcontrib><creatorcontrib>Sahakian, Alan V.</creatorcontrib><creatorcontrib>Swiryn, Steven</creatorcontrib><title>Abrupt changes in fibrillatory wave characteristics at the termination of paroxysmal atrial fibrillation in humans</title><title>Europace (London, England)</title><addtitle>Europace</addtitle><description>Aims We investigated the process of spontaneous termination of atrial fibrillation (AF) to determine its time course from the surface ECG. Methods and results We studied fibrillatory waves in Holter recordings of paroxysmal and sustained AF. Following QRS-T cancellation dominant frequencies (DFs) were computed and the relationship of DF to termination was scrutinized. For 57 episodes of paroxysmal AF (PAF) in 24 patients, DF ranged from 4.4 to 6.5 Hz (5.2 ± 0.4 Hz) compared to 5.8 to 7.4 Hz (6.6 ± 0.6 Hz) for sustained AF recordings. Comparison of the atrial frequency of the ultimate to the penultimate second demonstrated a drop in frequency in 51 of 57 episodes, P &lt; 0.00001. No comparable change was seen at longer time periods. Moments of comparably low frequency without termination were only occasionally seen in patients with PAF but not in patients with sustained AF. Conclusion Low frequency fibrillation was found to be much more likely to terminate. Frequency changes preceding spontaneous termination were abrupt, in contrast to the gradual frequency drop reported with drug-induced termination. The analysis of fibrillatory wave characteristics and their change over time might be used to target specific moments for pacing therapy in patients with AF.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Atrial Fibrillation - physiopathology</subject><subject>Electrocardiography, Ambulatory</subject><subject>Female</subject><subject>Fourier Analysis</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Predictive Value of Tests</subject><subject>Signal Processing, Computer-Assisted</subject><issn>1099-5129</issn><issn>1532-2092</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqFkU1LxDAQhoMoun6cvUnw4EGoO0napjku4hcIXvRcpmnqZtk2NWnV_fdm2VXBi6cZJs88DHkJOWVwxUCJqRm961Gb2LSg8h0yYZngCQfFd2MPSiUZ4-qAHIawAADJVbZPDpjMUshzMSF-VvmxH6ieY_dqArUdbWzl7XKJg_Mr-oHvZv3oUQ_G2zBYHSgOdJgbGget7XCwrqOuoT1697kKLS4j4G0sP6Y1Ec3zscUuHJO9BpfBnGzrEXm5vXm-vk8en-4ermePiRZS5QlHU7AapUFdyUZXtYIGsyatIOMcslRUOQpeF1DrnCldgGQs51KlKcOcIYojcrHx9t69jSYMZWuDNvGezrgxlBKkKCCTETz_Ay7c6Lt4W8lUIYDJYg1NN5D2LgRvmrL3tkW_KhmU6yzK7yzKTRZx42yrHavW1L_89vMjcLkB3Nj_a_sCjaiYzg</recordid><startdate>200707</startdate><enddate>200707</enddate><creator>Petrutiu, Simona</creator><creator>Sahakian, Alan V.</creator><creator>Swiryn, Steven</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200707</creationdate><title>Abrupt changes in fibrillatory wave characteristics at the termination of paroxysmal atrial fibrillation in humans</title><author>Petrutiu, Simona ; Sahakian, Alan V. ; Swiryn, Steven</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3796-2ae81da7eacb7fcbd90fa5f4b05220543b6a32d80dc619c807116279441a61aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Atrial Fibrillation - physiopathology</topic><topic>Electrocardiography, Ambulatory</topic><topic>Female</topic><topic>Fourier Analysis</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Predictive Value of Tests</topic><topic>Signal Processing, Computer-Assisted</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Petrutiu, Simona</creatorcontrib><creatorcontrib>Sahakian, Alan V.</creatorcontrib><creatorcontrib>Swiryn, Steven</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Europace (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Petrutiu, Simona</au><au>Sahakian, Alan V.</au><au>Swiryn, Steven</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abrupt changes in fibrillatory wave characteristics at the termination of paroxysmal atrial fibrillation in humans</atitle><jtitle>Europace (London, England)</jtitle><addtitle>Europace</addtitle><date>2007-07</date><risdate>2007</risdate><volume>9</volume><issue>7</issue><spage>466</spage><epage>470</epage><pages>466-470</pages><issn>1099-5129</issn><eissn>1532-2092</eissn><abstract>Aims We investigated the process of spontaneous termination of atrial fibrillation (AF) to determine its time course from the surface ECG. Methods and results We studied fibrillatory waves in Holter recordings of paroxysmal and sustained AF. Following QRS-T cancellation dominant frequencies (DFs) were computed and the relationship of DF to termination was scrutinized. For 57 episodes of paroxysmal AF (PAF) in 24 patients, DF ranged from 4.4 to 6.5 Hz (5.2 ± 0.4 Hz) compared to 5.8 to 7.4 Hz (6.6 ± 0.6 Hz) for sustained AF recordings. Comparison of the atrial frequency of the ultimate to the penultimate second demonstrated a drop in frequency in 51 of 57 episodes, P &lt; 0.00001. No comparable change was seen at longer time periods. Moments of comparably low frequency without termination were only occasionally seen in patients with PAF but not in patients with sustained AF. Conclusion Low frequency fibrillation was found to be much more likely to terminate. Frequency changes preceding spontaneous termination were abrupt, in contrast to the gradual frequency drop reported with drug-induced termination. The analysis of fibrillatory wave characteristics and their change over time might be used to target specific moments for pacing therapy in patients with AF.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>17540663</pmid><doi>10.1093/europace/eum096</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier ISSN: 1099-5129
ispartof Europace (London, England), 2007-07, Vol.9 (7), p.466-470
issn 1099-5129
1532-2092
language eng
recordid cdi_proquest_miscellaneous_70738057
source Oxford Open
subjects Adult
Aged
Aged, 80 and over
Atrial Fibrillation - physiopathology
Electrocardiography, Ambulatory
Female
Fourier Analysis
Humans
Male
Middle Aged
Predictive Value of Tests
Signal Processing, Computer-Assisted
title Abrupt changes in fibrillatory wave characteristics at the termination of paroxysmal atrial fibrillation in humans
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T21%3A16%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_TOX&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Abrupt%20changes%20in%20fibrillatory%20wave%20characteristics%20at%20the%20termination%20of%20paroxysmal%20atrial%20fibrillation%20in%20humans&rft.jtitle=Europace%20(London,%20England)&rft.au=Petrutiu,%20Simona&rft.date=2007-07&rft.volume=9&rft.issue=7&rft.spage=466&rft.epage=470&rft.pages=466-470&rft.issn=1099-5129&rft.eissn=1532-2092&rft_id=info:doi/10.1093/europace/eum096&rft_dat=%3Cproquest_TOX%3E70738057%3C/proquest_TOX%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c3796-2ae81da7eacb7fcbd90fa5f4b05220543b6a32d80dc619c807116279441a61aa3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=198301787&rft_id=info:pmid/17540663&rft_oup_id=10.1093/europace/eum096&rfr_iscdi=true