Iron overload in myelodysplastic syndromes: A Canadian consensus guideline

Abstract In December 2005, 11 Canadian hematologists met to develop an evidence-based clinical practice guideline that would address the diagnosis, monitoring, management, and rationale for the treatment of transfusional iron overload in patients with myelodysplastic syndromes (MDS). This Expert Pan...

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Bibliographic Details
Published in:Leukemia research 2008-09, Vol.32 (9), p.1338-1353
Main Authors: Wells, Richard A, Leber, Brian, Buckstein, Rena, Lipton, Jeffrey H, Hasegawa, Wanda, Grewal, Kuljit, Yee, Karen, Olney, Harold J, Larratt, Loree, Vickars, Linda, Tinmouth, Alan
Format: Article
Language:English
Subjects:
Canada
Deferasirox
Deferoxamine
Deferriprone
Desferal
Exjade
Ferriprox
Guideline
Hematology, Oncology and Palliative Medicine
Humans
Iron Chelating Agents - therapeutic use
Iron chelation
Iron overload
Iron Overload - drug therapy
Iron Overload - etiology
Myelodysplastic syndromes
Myelodysplastic Syndromes - complications
Myelodysplastic Syndromes - therapy
Prognosis
Secondary hemosiderosis
Transfusion
Transfusion Reaction
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Summary:Abstract In December 2005, 11 Canadian hematologists met to develop an evidence-based clinical practice guideline that would address the diagnosis, monitoring, management, and rationale for the treatment of transfusional iron overload in patients with myelodysplastic syndromes (MDS). This Expert Panel consisted of hematologists from across Canada, each with an active practice in a major population centre or a rural area. Based on an extensive literature search and years of clinical experience, their mandate was to address common clinical practice questions, particularly why treat, whom to treat, when to initiate treatment, and how to treat iron overload in patients with MDS.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2008.02.021