Lack of association between level of Plasminogen Activator Inhibitor-1 and estimates of tumor angiogenesis in early breast cancer

Plasminogen Activator Inhibitor type-1 (PAI-1) is involved in tumor invasion and progression. High levels of PAI-1 are associated with poor prognosis in breast cancer, and PAI-1 has been shown to play a role in angiogenic processes. Since estimates of tumor angiogenesis may predict poor prognosis we...

Full description

Saved in:
Bibliographic Details
Published in:Acta oncologica 2007, Vol.46 (6), p.782-791
Main Authors: Vrou Offersen, Birgitte, Riisbro, Rikke, Knoop, Ann, Brünner, Nils, Overgaard, Jens
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
Breast Neoplasms - mortality
Breast Neoplasms - physiopathology
Disease Progression
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunohistochemistry
Middle Aged
Neovascularization, Pathologic
Pilot Projects
Plasminogen Activator Inhibitor 1 - analysis
Prognosis
Prospective Studies
Survival
Survival Rate
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Plasminogen Activator Inhibitor type-1 (PAI-1) is involved in tumor invasion and progression. High levels of PAI-1 are associated with poor prognosis in breast cancer, and PAI-1 has been shown to play a role in angiogenic processes. Since estimates of tumor angiogenesis may predict poor prognosis we studied the relationship between PAI-1 and estimates of angiogenesis in breast cancer. Tumor tissue specimens from 438 breast cancer patients were included. Median follow-up was 10.3 years. Protein levels of PAI-1 were measured using an ELISA. Angiogenesis scores were performed using a Chalkley grid. Median PAI-1 level was 0.70 ng/mg protein (range, 0 - 90 ng/mg protein) and median Chalkley count was 5.00 (range, 2.67 - 12.00). Chalkley counts were not correlated with PAI-1. In univariate analysis both increasing PAI-1 and increasing Chalkley counts evaluated as continuous parameters were significantly associated with poor disease-specific survival with RR 1.04 (95% CI 1.02 - 1.07) (p
ISSN:0284-186X
1651-226X
DOI:10.1080/02841860601116383