Biosignaling of mammalian Ste20-related kinases

Sterile 20 (ste20) protein is an upstream ser/thr kinase in yeast, and several mammalian Ste20-like (MST) kinases have been identified. This review focuses on the signal transduction, interacting proteins, and potential biological function of MST1, 2, 3, and 4 kinases, since several novel signal pat...

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Bibliographic Details
Published in:Cellular signalling 2008-07, Vol.20 (7), p.1237-1247
Main Authors: Ling, Pin, Lu, Te-Jung, Yuan, Chiun-Jye, Lai, Ming-Derg
Format: Article
Language:English
Subjects:
Animals
Apoptosis contents
Humans
Kinase
Mammals - metabolism
MST
Protein-Serine-Threonine Kinases - metabolism
Signal pathway
Signal Transduction
ste20
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Summary:Sterile 20 (ste20) protein is an upstream ser/thr kinase in yeast, and several mammalian Ste20-like (MST) kinases have been identified. This review focuses on the signal transduction, interacting proteins, and potential biological function of MST1, 2, 3, and 4 kinases, since several novel signal pathways of these kinases have been characterized recently. MST1 and MST2 kinases play an important role in cell growth and apoptosis, and the signal pathways involves many important molecules including RAS, AKT, and FOXO3. MST3 and MST4 have similar kinase domain, but have opposite effects on apoptosis and transformation. The downstream signaling molecules of these two kinases are beginning to be elucidated. Based on the expression pattern and signal pathways, we will discuss the perspective biological functions of four MST family kinases in cancer, immune, cardiovascular, and brain function.
ISSN:0898-6568
1873-3913
DOI:10.1016/j.cellsig.2007.12.019