Changes in Hepatitis a Virus Seroepidemiology in Hiv-Infected Brazilian Patients

Shifting of hepatitis A virus (HAV) epidemiology from a high towards an intermediate endemicity pattern and use of antiretroviral therapy increased the risk of HIV/HAV coinfection in developing countries. The aim of this study was to investigate the presence of HAV markers in a cohort of HIV-infecte...

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Bibliographic Details
Published in:International journal of STD & AIDS 2008-05, Vol.19 (5), p.321-326
Main Authors: Aloise, R, De Almeida, A J, Sion, F S, Morais-De-SÁ, C A, Gaspar, A M C, De Paula, V S
Format: Article
Language:English
Subjects:
Adolescent
Adult
AIDS/HIV
Biological and medical sciences
Brazil - epidemiology
Child
Child, Preschool
Cohort Studies
Female
General aspects
Hepatitis A Antibodies - blood
Hepatitis A Vaccines - administration & dosage
Hepatitis A Vaccines - therapeutic use
Hepatitis A virus
Hepatitis A virus - immunology
Hepatitis A virus - isolation & purification
HIV Infections - complications
HIV Infections - virology
Human immunodeficiency virus
Human viral diseases
Humans
Infant
Infectious diseases
Male
Medical sciences
Middle Aged
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral hepatitis
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Summary:Shifting of hepatitis A virus (HAV) epidemiology from a high towards an intermediate endemicity pattern and use of antiretroviral therapy increased the risk of HIV/HAV coinfection in developing countries. The aim of this study was to investigate the presence of HAV markers in a cohort of HIV-infected patients from 1988 to 2004. The presence of serum anti-HAV antibodies and HAV-RNA by real-time polymerase chain reaction was investigated in 581 patients. Total anti-HAV antibodies was found in 464/581 (79.8%) patients, however, achanging epidemiologic pattern of hepatitis A among HIV-infected patients from 1988 to 2004 was observed. Among patients susceptible to HAV (n = 117), 5 (4.2%) were co-infected with HAV, all of them had IgM anti-HAV antibodies and were serum HAV-RNA-positive. The high prevalence of anti-HAV antibodies in HIV-infected patients suggests that screening tests for anti-HAV antibodies should be performed before implementation of hepatitis A vaccination, especially in those patients from endemic countries.
ISSN:0956-4624
1758-1052
DOI:10.1258/ijsa.2007.007100