Insight into the role of inositol phosphoglycans in insulin response and the regulation of glucose and lipid metabolism illustrated by the response of adipocytes from two strains of rats

Differences in biochemical and hormone profiles between two strains of rats provide insights into the relationships between insulin response, inositol phosphoglycans and lipid metabolism in adipose tissue. The results suggest the apparent anomaly of a higher rate of lipogenesis and response to insul...

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Bibliographic Details
Published in:Molecular genetics and metabolism 2008-06, Vol.94 (2), p.263-266
Main Authors: Kunjara, S., McLean, P., Greenbaum, A.L., Rademacher, T.W.
Format: Article
Language:English
Subjects:
Active/total and isoforms of lipogenic enzymes
Adipocytes
Adipose tissue
Adipose Tissue - metabolism
Animals
cAMP
Cyclic AMP - metabolism
Glucose - metabolism
Inositol Phosphates - chemistry
Inositol Phosphates - metabolism
Inositol phosphoglycans
Insulin - metabolism
Insulin response
Leptin
Leptin - metabolism
Lipid Metabolism
Lipogenesis
Liver - metabolism
Obesity
Polysaccharides - chemistry
Polysaccharides - metabolism
Rats
Rats, Wistar
Species Specificity
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Summary:Differences in biochemical and hormone profiles between two strains of rats provide insights into the relationships between insulin response, inositol phosphoglycans and lipid metabolism in adipose tissue. The results suggest the apparent anomaly of a higher rate of lipogenesis and response to insulin with a lower fat pad weight in the Charles River vs. Harlan Olac group relates to: (i) enzyme pre-programming with IPG-A, (ii) faster turnover of lipid, (iii) effects of leptin and cAMP.
ISSN:1096-7192
1096-7206
DOI:10.1016/j.ymgme.2008.02.006