Myocardial Tissue Doppler Changes in Patients with Bronchopulmonary Dysplasia

Objective To determine whether tissue Doppler measurements provide sensitive measures of right ventricular function that correlate with the severity of bronchopulmonary dysplasia (BPD). Study design 21 subjects (6 control subjects with no/mild BPD, 7 patients with moderate BPD, and 8 patients with s...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of pediatrics 2008-06, Vol.152 (6), p.766-770.e1
Main Authors: Yates, Andrew R., MD, Welty, Stephen E., MD, Gest, Alfred L., MD, Cua, Clifford L., MD
Format: Article
Language:English
Subjects:
Biological and medical sciences
Bronchopulmonary Dysplasia - diagnosis
Bronchopulmonary Dysplasia - physiopathology
Echocardiography, Doppler
Female
General aspects
Humans
Infant
Infant, Newborn
Male
Medical sciences
Pediatrics
Pneumology
Respiratory system : syndromes and miscellaneous diseases
Sensitivity and Specificity
Severity of Illness Index
Ventricular Function, Right
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective To determine whether tissue Doppler measurements provide sensitive measures of right ventricular function that correlate with the severity of bronchopulmonary dysplasia (BPD). Study design 21 subjects (6 control subjects with no/mild BPD, 7 patients with moderate BPD, and 8 patients with severe BPD) underwent limited echocardiograms with standard M-mode, mitral and tricuspid inflow velocities, and tissue Doppler features measured. BPD severity was scored by using the NICHD/NHLBI/ORD workshop rating scale by physicians blinded to the echocardiogram results. Groups were compared by using 1-way analysis of variance with post-hoc testing and linear regression. Results Patients with moderate BPD had a higher early Doppler inflow velocity to the early tissue Doppler velocity ratio (E/E′ ratio; P = .03), corresponding to increased end diastolic pressure, compared with patients with no/mild BPD. Patients with severe BPD had a higher E/E′ ratio ( P = .004) than patients with no/mild BPD. Linear regression demonstrated a correlation between BPD category and right ventricle E/E′ ( P = .007, R2 = 0.33) and left ventricular myocardial performance index ( P = .02, R2 = 0.28). Conclusion Increasing right ventricle E/E′ ratio correlates with clinical severity of BPD. Abnormal left ventricular myocardial performance index was noted to correlate with the grade of BPD. Further longitudinal studies of tissue Doppler echocardiographic assessment of cardiac function in premature infants with BPD are needed.
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2007.11.039