A case of recurrent non-small-cell lung carcinoma and paraneoplastic Cushing's syndrome

Secretion of ectopic adrenocorticotropic hormone (ACTH) with consequently Cushing's syndrome is a rare paraneoplastic phenomenon. It has been described in a variety of malignancies, like bronchial carcinoids, small-cell lung carcinoma, thymoma, pancreatic carcinoma and other. In many cases of s...

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Bibliographic Details
Published in:Lung cancer (Amsterdam, Netherlands) Netherlands), 2006-02, Vol.51 (2), p.251-255
Main Authors: Noorlander, I., Elte, J.W., Manintveld, O.C., Tournoy, K.G., Praet, M.M., van Meerbeeck, J.P., Aerts, J.G.
Format: Article
Language:English
Subjects:
ACTH Syndrome, Ectopic - etiology
Adrenals. Adrenal axis. Renin-angiotensin system (diseases)
Adrenocorticotropic Hormone - secretion
Biological and medical sciences
Carcinoma, Non-Small-Cell Lung - complications
Cushing
Cushing Syndrome - etiology
Ectopic ACTH
Endocrinopathies
Female
Humans
Lung Neoplasms - complications
Medical sciences
Middle Aged
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Non-small-cell lung carcinoma
Pneumology
Tumors of the respiratory system and mediastinum
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Summary:Secretion of ectopic adrenocorticotropic hormone (ACTH) with consequently Cushing's syndrome is a rare paraneoplastic phenomenon. It has been described in a variety of malignancies, like bronchial carcinoids, small-cell lung carcinoma, thymoma, pancreatic carcinoma and other. In many cases of suspected ectopic ACTH secretion, it is difficult to histologically or cytochemically confirm the diagnosis. We present a 63-year-old woman with a recurrent poorly differentiated squamous cell lung carcinoma with clinical and biochemical features consistent with ectopic Cushing's syndrome. Immunocytochemical staining confirmed the secretion of ACTH by tumour cells.
ISSN:0169-5002
1872-8332
DOI:10.1016/j.lungcan.2005.08.015