The Macrophage-Inducible C-Type Lectin, Mincle, Is an Essential Component of the Innate Immune Response to Candida albicans

The recognition of carbohydrate moieties by cells of the innate immune system is emerging as an essential element in antifungal immunity, but despite the number and diversity of lectins expressed by innate immune cells, few carbohydrate receptors have been characterized. Mincle, a C-type lectin, is...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2008-06, Vol.180 (11), p.7404-7413
Main Authors: Wells, Christine A, Salvage-Jones, Judith A, Li, Xin, Hitchens, Kelly, Butcher, Suzanne, Murray, Rachael Z, Beckhouse, Anthony G, Lo, Yu-Lan-Sandra, Manzanero, Silvia, Cobbold, Christian, Schroder, Kate, Ma, Bo, Orr, Sally, Stewart, Lauren, Lebus, Daniel, Sobieszczuk, Peter, Hume, David A, Stow, Jennifer, Blanchard, Helen, Ashman, Robert B
Format: Article
Language:English
Subjects:
Animals
Candida albicans
Candida albicans - immunology
Candida albicans - metabolism
Candidiasis - immunology
Cell Line
Disease Susceptibility
Humans
Immunity, Innate
Lectins, C-Type - genetics
Lectins, C-Type - immunology
Lectins, C-Type - metabolism
Macrophages - cytology
Macrophages - immunology
Macrophages - metabolism
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Knockout
Phagocytosis
Phagosomes - immunology
Phagosomes - metabolism
Toll-Like Receptor 2 - immunology
Toll-Like Receptor 2 - metabolism
Tumor Necrosis Factor-alpha - immunology
Tumor Necrosis Factor-alpha - metabolism
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Summary:The recognition of carbohydrate moieties by cells of the innate immune system is emerging as an essential element in antifungal immunity, but despite the number and diversity of lectins expressed by innate immune cells, few carbohydrate receptors have been characterized. Mincle, a C-type lectin, is expressed predominantly on macrophages, and is here shown to play a role in macrophage responses to the yeast Candida albicans. After exposure to the yeast in vitro, Mincle localized to the phagocytic cup, but it was not essential for phagocytosis. In the absence of Mincle, production of TNF-alpha by macrophages was reduced, both in vivo and in vitro. In addition, mice lacking Mincle showed a significantly increased susceptibility to systemic candidiasis. Thus, Mincle plays a novel and nonredundant role in the induction of inflammatory signaling in response to C. albicans infection.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.180.11.7404