g.243A>G mutation in intron 17 of MUC4 is significantly associated with susceptibility/resistance to ETEC F4ab/ac infection in pigs

Using a porcine radiation hybrid panel, we assigned the mucin 4 (MUC4) gene to SSC13q41, which harbours the enterotoxigenic Escherichia coli (ETEC) F4ab/ac receptor locus. In addition, we identified two SNPs in intron 17 of MUC4 (DQ124298:g.243A>G and DQ124298:g.334A>G) in the parental populat...

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Bibliographic Details
Published in:Animal genetics 2007-08, Vol.38 (4), p.397-400
Main Authors: Peng, Q.-L, Ren, J, Yan, X.-M, Huang, X, Tang, H, Wang, Y.-Z, Zhang, B, Huang, L.-S
Format: Article
Language:English
Subjects:
adhesion
Animals
association
Escherichia coli
Escherichia coli Infections - genetics
Escherichia coli Infections - veterinary
Female
Immunity, Innate - genetics
infection
Introns
Linkage Disequilibrium
Male
MUC4
Mucin-4
Mucins - genetics
Polymorphism, Single Nucleotide
porcine
Radiation Hybrid Mapping
SNP
Swine
Swine Diseases - genetics
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Summary:Using a porcine radiation hybrid panel, we assigned the mucin 4 (MUC4) gene to SSC13q41, which harbours the enterotoxigenic Escherichia coli (ETEC) F4ab/ac receptor locus. In addition, we identified two SNPs in intron 17 of MUC4 (DQ124298:g.243A>G and DQ124298:g.334A>G) in the parental population of a White Duroc x Erhualian cross. Association analysis showed that the MUC4 g.243A>G mutation was strongly associated with ETEC F4ab/ac, and especially with F4ac adhesion phenotypes in the White Duroc x Erhualian resource population, indicating that this polymorphism was in a significant linkage disequlibrium with the ETEC F4ab/ac receptor locus. Because of different linkage disequlibrium values between the ETEC F4ab and F4ac adhesion phenotypes and the MUC4 g.243A>G mutation, we argue that the inheritance of F4ab and F4ac receptors might be under the control of two closely linked loci.
ISSN:0268-9146
1365-2052
DOI:10.1111/j.1365-2052.2007.01608.x