Astrocytic activation in relation to inflammatory markers during clinical exacerbation of relapsing-remitting multiple sclerosis

The study aimed to assay the cerebrospinal fluid (CSF) levels of protein S100B, a biomarker of astrocyte activation in relation to kynurenic acid (KYNA) and nitric oxide (NO) metabolites, nitrate/nitrite (NOx) concentrations in acute relapse multiple sclerosis (MS) patients. Twenty relapsing-remitti...

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Bibliographic Details
Published in:Journal of Neural Transmission 2007-08, Vol.114 (8), p.1011-1015
Main Authors: Rejdak, K, Petzold, A, Kocki, T, Kurzepa, J, Grieb, P, Turski, W A, Stelmasiak, Z
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Astrocytes - immunology
Astrocytes - metabolism
Biomarkers - analysis
Biomarkers - cerebrospinal fluid
Brain - immunology
Brain - metabolism
Brain - physiopathology
Encephalitis - cerebrospinal fluid
Encephalitis - immunology
Encephalitis - physiopathology
Female
Gliosis - cerebrospinal fluid
Gliosis - immunology
Gliosis - physiopathology
Humans
Kynurenic Acid - analysis
Kynurenic Acid - cerebrospinal fluid
Male
Multiple Sclerosis, Relapsing-Remitting - cerebrospinal fluid
Multiple Sclerosis, Relapsing-Remitting - immunology
Multiple Sclerosis, Relapsing-Remitting - physiopathology
Nerve Growth Factors - analysis
Nerve Growth Factors - cerebrospinal fluid
Nitrates - analysis
Nitrates - cerebrospinal fluid
Nitric Oxide - metabolism
Nitrites - analysis
Nitrites - cerebrospinal fluid
Predictive Value of Tests
Recurrence
S100 Calcium Binding Protein beta Subunit
S100 Proteins - analysis
S100 Proteins - cerebrospinal fluid
Sensitivity and Specificity
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Summary:The study aimed to assay the cerebrospinal fluid (CSF) levels of protein S100B, a biomarker of astrocyte activation in relation to kynurenic acid (KYNA) and nitric oxide (NO) metabolites, nitrate/nitrite (NOx) concentrations in acute relapse multiple sclerosis (MS) patients. Twenty relapsing-remitting MS (RR-MS) patients and 10 controls were enrolled. RR-MS patients were assessed on the expanded disability status scale (EDSS) and underwent lumbar puncture. The CSF KYNA, NOx and S100B levels were significantly higher in RR-MS group compared to controls (p = 0.01, 0.001, 0.04, respectively). There was a significant correlation between CSF S100B and KYNA (p = 0.01) but not NOx (p > 0.05) in RR-MS. CSF KYNA, NOx or S100B concentrations did not correlate with disease characteristics of MS patients. Our study suggests the activation of the kynurenine pathway leading to the increase of neuroprotective KYNA in the CSF of MS patients during acute relapse what contrasts with chronic phases of the disease.
ISSN:0300-9564
1435-1463
DOI:10.1007/s00702-007-0667-y