Aldosterone as a Cardiovascular Risk Hormone

The pathophysiological role of aldosterone in the development of cardiovascular disease has long been considered to be due its potent volume expansion/hypertensive effect mainly via mineralocorticoid receptor (MR) expressed in renal tubular epithelial cells. However, recent accumulating lines of evi...

Full description

Saved in:
Bibliographic Details
Published in:ENDOCRINE JOURNAL 2007, Vol.54(3), pp.359-370
Main Authors: YOSHIMOTO, Takanobu, HIRATA, Yukio
Format: Article
Language:English
Subjects:
Aldosterone
Aldosterone - physiology
Angiotensin
Angiotensin II - physiology
Animals
Cardiovascular Diseases - etiology
Epithelial Cells - metabolism
Humans
Mineralocorticoid receptor
Models, Biological
Oxidative stress
Oxidative Stress - physiology
Receptors, Mineralocorticoid - metabolism
Risk Factors
Vascular
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The pathophysiological role of aldosterone in the development of cardiovascular disease has long been considered to be due its potent volume expansion/hypertensive effect mainly via mineralocorticoid receptor (MR) expressed in renal tubular epithelial cells. However, recent accumulating lines of evidence from clinical and experimental studies have suggested that direct cardiovascular effect of aldosterone contributes to the development of cardiovascular injury via MRs in non-epithelial tissue. A series of recent clinical studies have revealed that patients with primary aldosteronism have higher incidence of cardiovascular and renal complications than those with essential hypertension, and that aldosterone antagonism has cardiovascular protective effect in patients with heart failure independent from blood pressure. Numerous experimental studies have shown that both inflammation and oxidative stress play an initial and key role in the development of aldosterone-induced cardiovascular injury via non-epithelial MR activation. In this review, we discuss recent research progress in aldosterone and MR effects, with special emphasis on the pathophysiological role of aldosterone in cardiovascular diseases and the possible molecular mechanism(s) of cardiovascular injury by non-epithelial MR activation.
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.KR-80