Terbinafine susceptibility patterns for onychomycosis-causative dermatophytes and Scopulariopsis brevicaulis

Abstract The in vitro antifungal activity of terbinafine against 521 clinical isolates of seven species of dermatophytes, including four onychomycosis-causative species, as well as five Scopulariopsis brevicaulis isolates was determined by a modified Clinical and Laboratory Standards Institute micro...

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Bibliographic Details
Published in:International journal of antimicrobial agents 2008-06, Vol.31 (6), p.540-543
Main Authors: Carrillo-Muñoz, Alfonso-Javier, Giusiano, Gustavo, Cárdenes, Delia, Hernández-Molina, Juan-Manuel, Eraso, Elena, Quindós, Guillermo, Guardia, Celia, del Valle, Oscar, Tur-Tur, Cristina, Guarro, Josep
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal
Antifungal Agents - pharmacology
Arthrodermataceae - drug effects
Biological and medical sciences
Culture Media
Dermatophytes
Dermatophytosis
Epidermophyton
Human mycoses
Infectious Disease
Infectious diseases
Itraconazole - pharmacology
Medical sciences
Microbial Sensitivity Tests
Microsporum
Mycoses
Mycoses of the skin
Naphthalenes - pharmacology
Onychomycosis - microbiology
Pharmacology. Drug treatments
Scopulariopsis
Scopulariopsis brevicaulis
Terbinafine
Trichophyton
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Summary:Abstract The in vitro antifungal activity of terbinafine against 521 clinical isolates of seven species of dermatophytes, including four onychomycosis-causative species, as well as five Scopulariopsis brevicaulis isolates was determined by a modified Clinical and Laboratory Standards Institute microdilution method. Results showed a high antifungal activity of terbinafine against all dermatophyte isolates (geometric minimal inhibitory concentration (MIC) = 0.026 μg/mL; concentration inhibiting 50% of mycological growth (MIC50 ) = 0.03 μg/mL; and concentration inhibiting 90% of mycological growth (MIC90 ) = 0.06 μg/mL). The geometric mean MICs against onychomycosis-causative dermatophyte species was lower (0.024 μg/mL) than the global MIC. However, the in vitro activity of terbinafine against S. brevicaulis was considerably lower (geometric mean MIC = 1.38 μg/mL) in comparison with dermatophytes. The antifungal activity of itraconazole was lower than that of terbinafine against these fungi. These data confirm the high in vitro antifungal activity of terbinafine against dermatophytes, under standardised conditions.
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2008.01.023