Antigenic characterization of phocine distemper virus causing mass mortality in 2002 and its relationship to other morbilliviruses

The antigenic relationship between the phocine distemper virus (PDV) strain causing the epidemic in 2002 and the PDV strain of 1988, canine distemper virus from two dogs and one marten, and one measles virus strain was investigated in vivo and in vitro using monospecific polyclonal and monoclonal an...

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Bibliographic Details
Published in:Archives of virology 2007-08, Vol.152 (8), p.1559-1564
Main Authors: Wohlsein, P, Müller, G, Haas, L, Siebert, U, Harder, T. C, Baumgärtner, W
Format: Article
Language:English
Subjects:
Animals
Antibody Specificity
Antigens, Viral - immunology
Antigens, Viral - metabolism
Biological and medical sciences
Canine distemper virus
Cell culture
Cercopithecus aethiops
Disease Outbreaks
Distemper - epidemiology
Distemper - mortality
Distemper - virology
Distemper Virus, Canine - classification
Distemper Virus, Canine - immunology
Distemper Virus, Phocine - classification
Distemper Virus, Phocine - immunology
Distemper Virus, Phocine - isolation & purification
Distemper Virus, Phocine - pathogenicity
Dogs
Epidemics
Epitope Mapping
Fundamental and applied biological sciences. Psychology
Genes
Marine mammals
Measles
Measles virus
Microbiology
Miscellaneous
Monoclonal antibodies
Morbillivirus - classification
Morbillivirus - immunology
Morbillivirus Infections
Mustelidae - virology
Phocine distemper virus
Proteins
Seals, Earless - virology
Vaccines
Vero Cells
Veterinary medicine
Viral Proteins - immunology
Viral Proteins - metabolism
Virology
Viruses
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Summary:The antigenic relationship between the phocine distemper virus (PDV) strain causing the epidemic in 2002 and the PDV strain of 1988, canine distemper virus from two dogs and one marten, and one measles virus strain was investigated in vivo and in vitro using monospecific polyclonal and monoclonal antibodies directed against five different proteins of canine or phocine distemper virus (N, P, M, F, H). Epitopic mapping revealed no difference between the PDV strains causing the epidemics in 1988 or 2002. However, the use of these antibodies allowed discrimination between different morbilliviruses including a vaccine strain of canine distemper virus. The major differences among the investigated morbilliviruses were found in the H protein.
ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-007-0970-9