Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours

Solid tumours are complex structures in which the interdependent relationship between tumour and endothelial cells modulates tumour development and metastasis dissemination. The tumour microenvironment plays an important role in this cell interplay, and changes in its features have a major impact on...

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Bibliographic Details
Published in:The FEBS journal 2008-06, Vol.275 (12), p.2991-3002
Main Authors: Toffoli, S, Michiels, C
Format: Article
Language:English
Subjects:
Animals
apoptosis
Biochemistry
cancer
Cell Hypoxia
Cell Survival
Cellular biology
chemoresistance
endothelial cell
Endothelial Cells - metabolism
Humans
Hypoxia
Hypoxia-Inducible Factor 1, alpha Subunit - metabolism
hypoxia‐inducible factor‐1
intermittent hypoxia
Mice
Neoplasms - blood supply
Neoplasms - genetics
Neoplasms - metabolism
radioresistance
reactive oxygen species
reoxygenation
Transcription, Genetic
tumor cell
Tumors
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Summary:Solid tumours are complex structures in which the interdependent relationship between tumour and endothelial cells modulates tumour development and metastasis dissemination. The tumour microenvironment plays an important role in this cell interplay, and changes in its features have a major impact on tumour growth as well as on anticancer therapy responsiveness. Different studies have shown irregular blood flow in tumours, which is responsible for hypoxia and reoxygenation phases, also called intermittent hypoxia. Intermittent hypoxia induces transient changes, the impact of which has been underestimated for a long time. Recent in vitro and in vivo studies have shown that intermittent hypoxia could positively modulate tumour development, inducing tumour growth, angiogenic processes, chemoresistance, and radioresistance. In this article, we review the effects of intermittent hypoxia on tumour and endothelial cells as well as its impacts on tumour development.
ISSN:1742-464X
1742-4658
DOI:10.1111/j.1742-4658.2008.06454.x