Endothelial dysfunction, ambulatory pulse pressure and albuminuria are associated in Type 2 diabetic subjects

• Published in: Diabetic medicine 2007-08, Vol.24 (8), p.911-915
• Main Authors: Knudsen, S. T., Jeppesen, P., Frederiksen, C. A., Andersen, N. H., Bek, T., Ingerslev, J., Mogensen, C. E., Poulsen, P. L.
• Format: Article
• Language: English
• Subjects: Aged; Albuminuria - physiopathology; ambulatory blood pressure; Biological and medical sciences; Blood Pressure - physiology; Blood Pressure Monitoring, Ambulatory - methods; Cardiovascular Diseases - physiopathology; diabetes; Diabetes Mellitus, Type 2 - physiopathology; Diabetes. Impaired glucose tolerance; Diabetic Angiopathies - physiopathology; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; endothelial dysfunction; Endothelium, Vascular - physiopathology; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Humans; Male; Medical sciences; Middle Aged; nephropathy; pulse pressure; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: endocrinology; von Willebrand Factor - analysis
• ISSN: 0742-3071; 1464-5491
• DOI: 10.1111/j.1464-5491.2007.02197.x

Aim  Elevated pulse pressure (PP) is associated with microvascular complications in Type 2 diabetic patients. In non‐diabetic subjects, elevated PP has been associated with endothelial dysfunction. The relation between endothelial dysfunction and PP in diabetic subjects has not previously been examined. We examined the relation between PP, markers of endothelial activation and albuminuria in Type 2 diabetic patients. Methods  In 46 Type 2 diabetic patients and 19 non‐diabetic subjects, we performed 24‐h ambulatory blood pressure (AMBP) monitoring. Urinary albumin excretion rate was measured as three urinary albumin/creatinine ratios. Von Willebrand factor (vWF), fibrinogen, E‐selectin and soluble intercellular adhesion molecule 1 (ICAM‐1) were measured in plasma. Results  Thirty‐four patients had normoalbuminuria (group N) and 12 had micro‐ or macroalbuminuria (group A). PP levels increased in a stepwise manner from the control group (group C) to group N and group A; night PP 43 ± 5, 48 ± 10 and 59 ± 12 mmHg (groups C, N and A, respectively, P