Mucin (Qniumucin), a Glycoprotein from Jellyfish, and Determination of Its Main Chain Structure

We extracted a novel glycoprotein, a member of the mucin family, from five species of jellyfish with high yields (1%−3% dry weight, 0.02%−0.1% wet weight) and determined its main chain structure and molecular mass. The glycoprotein contains unique tandem repeats of eight amino acids, of which two th...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2007-07, Vol.70 (7), p.1089-1092
Main Authors: Masuda, Akiko, Baba, Takayuki, Dohmae, Naoshi, Yamamura, Masahiro, Wada, Hiroo, Ushida, Kiminori
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Analytical, structural and metabolic biochemistry
Animals
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
galactosamine
General aspects, investigation methods
glycoproteins
glycosylation
Humans
Marine Biology
Mucin 5AC
mucins
Mucins - chemistry
Mucins - isolation & purification
Proteins
qniumucin
Scyphozoa
Scyphozoa - chemistry
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Summary:We extracted a novel glycoprotein, a member of the mucin family, from five species of jellyfish with high yields (1%−3% dry weight, 0.02%−0.1% wet weight) and determined its main chain structure and molecular mass. The glycoprotein contains unique tandem repeats of eight amino acids, of which two threonine residues are probably glycosylated by N-acetyl-d-galactosamine (GalNAc). We named this substance, which is common in jellyfish and similar to the human mucin MUC5AC, “qniumucin” and suggested the utilization of this compound as a new marine resource.
ISSN:0163-3864
1520-6025
DOI:10.1021/np060341b