Effects of a synbiotic milk product on human intestinal ecosystem

To investigate the effect of prolonged consumption of a synbiotic milk (Synbiotic) containing Lactobacillus acidophilus (strain 74-2, 10⁷ CFU ml⁻¹), Bifidobacterium lactis (strain 420, 10⁷ CFU ml⁻¹) and 2% inulin on colonic ecosystem in healthy humans. A group of 26 healthy subjects, aged 22-47 year...

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Bibliographic Details
Published in:Journal of applied microbiology 2007-08, Vol.103 (2), p.499-506
Main Authors: Casiraghi, M.C, Canzi, E, Zanchi, R, Donati, E, Villa, L
Format: Article
Language:English
Subjects:
Adult
Bacteria - isolation & purification
bifidobacteria
Bifidobacterium lactis
Bile Acids and Salts - analysis
Biological and medical sciences
Colony Count, Microbial
Cultured Milk Products
Diet
Double-Blind Method
Ecosystem
faecal bile acids
Feces - chemistry
Feces - microbiology
Female
Fundamental and applied biological sciences. Psychology
Humans
Hydrogen-Ion Concentration
Intestines - microbiology
inulin
Lactic Acid - analysis
lactic acid bacteria
Lactobacillus acidophilus
Male
Microbiology
Middle Aged
Probiotics - administration & dosage
synbiotic
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Summary:To investigate the effect of prolonged consumption of a synbiotic milk (Synbiotic) containing Lactobacillus acidophilus (strain 74-2, 10⁷ CFU ml⁻¹), Bifidobacterium lactis (strain 420, 10⁷ CFU ml⁻¹) and 2% inulin on colonic ecosystem in healthy humans. A group of 26 healthy subjects, aged 22-47 years, participated in a 6-week placebo-controlled dietary intervention study. After a 2-week baseline period, in which all volunteers consumed 500 ml day⁻¹ of 2% skimmed milk (Placebo), the study was designed as a randomized, double-blind, two-armed parallel study in which 4-week consumption of 500 ml day portions of Synbiotic or Placebo were compared. Faecal microbial counts, pH, l-lactic acid and bile acid concentrations were assessed before and after the intervention. Synbiotic consumption significantly decreased faecal dry weight (P < 0·01) and l-lactic acid (P < 0·05) concentration, while significantly increased faecal bifidobacteria (P < 0·05) and lactobacilli (P < 0·01) counts. The tested synbiotic milk showed its synbiotic nature by enhancing the growth of bifidobacteria and lactobacilli. Scientific support to functional effect of a synbiotic milk.
ISSN:1364-5072
1365-2672
DOI:10.1111/j.1365-2672.2006.03273.x