Long-term results and prognostic factors of squamous cell carcinoma of the anal canal treated by irradiation

To analyze the prognostic factors of loco regional control (LRC), specific survival (SS) and sphincter conservation (SC) of patients treated by curative and conservative irradiation for an epidermoid cancer of anal canal in our institution. From 1976 to 2005, 286 patients (pts) were treated by exclu...

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Bibliographic Details
Published in:Cancer radiothérapie 2007-06, Vol.11 (4), p.169-177
Main Authors: Tournier-Rangeard, L, Peiffert, D, Lafond, C, Mege, A, Metayer, Y, Marchesi, V, Buchheit, I, Uwer, L, Conroy, T, Kaminsky, M-C
Format: Article
Language:fre
Subjects:
Adult
Aged
Aged, 80 and over
Anus Neoplasms - mortality
Anus Neoplasms - radiotherapy
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - radiotherapy
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prognosis
Survival Rate
Time Factors
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Summary:To analyze the prognostic factors of loco regional control (LRC), specific survival (SS) and sphincter conservation (SC) of patients treated by curative and conservative irradiation for an epidermoid cancer of anal canal in our institution. From 1976 to 2005, 286 patients (pts) were treated by exclusive radiotherapy (180 pts) or chemo-radiotherapy (106 pts) followed by a brachytherapy boost (233 pts) or external beam radiotherapy boost (24 pts). Forty-three pts were stage I, 154 stage II, 31 stage IIIA and 53 stage IIIB. The mean follow-up was 65 months (range: 1.3-250 months). The 5-years-overall survival and SS rates were 66.4% and 78.1% respectively. In multivariate analysis, tumor size (>or=40 mm) [RR=2.1], node involvement (RR=2.4), and poor response (
ISSN:1278-3218
DOI:10.1016/j.canrad.2007.02.001