Long-term results and prognostic factors of squamous cell carcinoma of the anal canal treated by irradiation

To analyze the prognostic factors of loco regional control (LRC), specific survival (SS) and sphincter conservation (SC) of patients treated by curative and conservative irradiation for an epidermoid cancer of anal canal in our institution. From 1976 to 2005, 286 patients (pts) were treated by exclu...

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Published in:Cancer radiothérapie 2007-06, Vol.11 (4), p.169-177
Main Authors: Tournier-Rangeard, L, Peiffert, D, Lafond, C, Mege, A, Metayer, Y, Marchesi, V, Buchheit, I, Uwer, L, Conroy, T, Kaminsky, M-C
Format: Article
Language:fre
Subjects:
Adult
Aged
Aged, 80 and over
Anus Neoplasms - mortality
Anus Neoplasms - radiotherapy
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - radiotherapy
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prognosis
Survival Rate
Time Factors
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container_end_page 177
container_issue 4
container_start_page 169
container_title Cancer radiothérapie
container_volume 11
creator Tournier-Rangeard, L
Peiffert, D
Lafond, C
Mege, A
Metayer, Y
Marchesi, V
Buchheit, I
Uwer, L
Conroy, T
Kaminsky, M-C
description To analyze the prognostic factors of loco regional control (LRC), specific survival (SS) and sphincter conservation (SC) of patients treated by curative and conservative irradiation for an epidermoid cancer of anal canal in our institution. From 1976 to 2005, 286 patients (pts) were treated by exclusive radiotherapy (180 pts) or chemo-radiotherapy (106 pts) followed by a brachytherapy boost (233 pts) or external beam radiotherapy boost (24 pts). Forty-three pts were stage I, 154 stage II, 31 stage IIIA and 53 stage IIIB. The mean follow-up was 65 months (range: 1.3-250 months). The 5-years-overall survival and SS rates were 66.4% and 78.1% respectively. In multivariate analysis, tumor size (>or=40 mm) [RR=2.1], node involvement (RR=2.4), and poor response (
doi_str_mv 10.1016/j.canrad.2007.02.001
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From 1976 to 2005, 286 patients (pts) were treated by exclusive radiotherapy (180 pts) or chemo-radiotherapy (106 pts) followed by a brachytherapy boost (233 pts) or external beam radiotherapy boost (24 pts). Forty-three pts were stage I, 154 stage II, 31 stage IIIA and 53 stage IIIB. The mean follow-up was 65 months (range: 1.3-250 months). The 5-years-overall survival and SS rates were 66.4% and 78.1% respectively. In multivariate analysis, tumor size (&gt;or=40 mm) [RR=2.1], node involvement (RR=2.4), and poor response (&lt;75%) to first course irradiation [RR=1.9], local relapse (RR=4.5) and distant metastases were factors of poor prognosis for SS. Five-years-LRC were 71.5% (88% for stage I, 69% for stage II, 77%, for stage IIIA and 60% for stage IIIB). Prognosis factors of LCR were tumor size (RR=2.5), response to first course of irradiation (RR=2.9). SC was 71% at 5 years. Prognosis factors of SC were tumor size (RR=1.9) and response to first course of irradiation (RR=2.4). The results of this series are similar to those of the literature. As well as initial tumor extension, response to first course of irradiation was found as prognostic factor on LCR, SS, SC. Our results are similar to other series and brachytherapy seems not to be deleterious. 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From 1976 to 2005, 286 patients (pts) were treated by exclusive radiotherapy (180 pts) or chemo-radiotherapy (106 pts) followed by a brachytherapy boost (233 pts) or external beam radiotherapy boost (24 pts). Forty-three pts were stage I, 154 stage II, 31 stage IIIA and 53 stage IIIB. The mean follow-up was 65 months (range: 1.3-250 months). The 5-years-overall survival and SS rates were 66.4% and 78.1% respectively. In multivariate analysis, tumor size (&gt;or=40 mm) [RR=2.1], node involvement (RR=2.4), and poor response (&lt;75%) to first course irradiation [RR=1.9], local relapse (RR=4.5) and distant metastases were factors of poor prognosis for SS. Five-years-LRC were 71.5% (88% for stage I, 69% for stage II, 77%, for stage IIIA and 60% for stage IIIB). Prognosis factors of LCR were tumor size (RR=2.5), response to first course of irradiation (RR=2.9). SC was 71% at 5 years. Prognosis factors of SC were tumor size (RR=1.9) and response to first course of irradiation (RR=2.4). The results of this series are similar to those of the literature. As well as initial tumor extension, response to first course of irradiation was found as prognostic factor on LCR, SS, SC. Our results are similar to other series and brachytherapy seems not to be deleterious. 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The results of this series are similar to those of the literature. As well as initial tumor extension, response to first course of irradiation was found as prognostic factor on LCR, SS, SC. Our results are similar to other series and brachytherapy seems not to be deleterious. Its impact to local control remains to be evaluated.</abstract><cop>France</cop><pmid>17400501</pmid><doi>10.1016/j.canrad.2007.02.001</doi><tpages>9</tpages></addata></record>
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subjects Adult
Aged
Aged, 80 and over
Anus Neoplasms - mortality
Anus Neoplasms - radiotherapy
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - radiotherapy
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prognosis
Survival Rate
Time Factors
title Long-term results and prognostic factors of squamous cell carcinoma of the anal canal treated by irradiation
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