Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis"

Taguchi et al. (Reports, 20 July 2007, p. 369) reported that mice heterozygous for a null mutation in insulin receptor substrate-2 (Irs2) display a 17% increase in median life span. However, using the same mouse model, we find no evidence for life-span extension and suggest that the findings of Tagu...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2008-05, Vol.320 (5879), p.1012; author reply 1012-1012
Main Authors: Selman, Colin, Lingard, Steven, Gems, David, Partridge, Linda, Withers, Dominic J
Format: Article
Language:English
Subjects:
Animals
Brain - metabolism
Crosses, Genetic
Diet
Female
Homeostasis
Insulin Receptor Substrate Proteins
Intracellular Signaling Peptides and Proteins - genetics
Intracellular Signaling Peptides and Proteins - metabolism
Kaplan-Meier Estimate
Longevity
Male
Mice
Mice, Inbred C57BL
Mutation
Phosphoproteins - genetics
Phosphoproteins - metabolism
Research Design
Signal Transduction
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Summary:Taguchi et al. (Reports, 20 July 2007, p. 369) reported that mice heterozygous for a null mutation in insulin receptor substrate-2 (Irs2) display a 17% increase in median life span. However, using the same mouse model, we find no evidence for life-span extension and suggest that the findings of Taguchi et al. were due to atypical life-span profiles in their study animals.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1152366