Fluoro-deoxy-glucose positron emission tomography for evaluation of indeterminate lung nodules: assigning a probability of malignancy may be preferable to binary readings

Objective To assess the diagnostic value of fluorine-18 fluoro-2-deoxy- d -glucose positron emission tomography (FDG-PET) using standard uptake values (SUV) in the differential diagnoses of indeterminate pulmonary nodules. Specifically, we assessed the probability of malignancy for various SUV range...

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Bibliographic Details
Published in:Annals of nuclear medicine 2008-04, Vol.22 (3), p.165-170
Main Authors: Kim, Suk C., Machac, Josef, Krynyckyi, Borys R., Knesaurek, Karin, Krellenstein, Daniel, Schultz, Barbara, Gribetz, Allen, DePalo, Louis, Teirstein, Alvin, Kim, Chun K.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Clinical Trials as Topic
Cohort Studies
Diagnosis, Differential
Female
Fluorodeoxyglucose F18 - pharmacokinetics
Humans
Image Interpretation, Computer-Assisted
Imaging
Lung Neoplasms - diagnostic imaging
Lung Neoplasms - pathology
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Staging
Nuclear Medicine
Original Article
Positron-Emission Tomography
Probability
Radiology
Radiopharmaceuticals - pharmacokinetics
ROC Curve
Solitary Pulmonary Nodule - classification
Solitary Pulmonary Nodule - diagnostic imaging
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Summary:Objective To assess the diagnostic value of fluorine-18 fluoro-2-deoxy- d -glucose positron emission tomography (FDG-PET) using standard uptake values (SUV) in the differential diagnoses of indeterminate pulmonary nodules. Specifically, we assessed the probability of malignancy for various SUV ranges, and compared the diagnostic efficacy of SUV with and without correction for partial volume effects on the basis of lesion size. Methods The FDG-PET scans performed on 158 patients with biopsy-proven pulmonary lesions seen on computed tomography (CT) scan were retrospectively reviewed. Histopathological confirmation was obtained to establish the diagnosis of the lesions. A region of interest (ROI) was drawn for each lesion, and FDG uptake was quantified (SUV raw ). The SUV raw values were normalized for the “size” of the pulmonary lesions measured on CT (SUV size ). Sensitivity and specificity of FDG-PET for pulmonary lesions
ISSN:0914-7187
1864-6433
DOI:10.1007/s12149-007-0112-1