Sentinel Lymph Node Biopsy (SLNB) in management of N0 stage T1 –T2 lip cancer as a “Same Day” procedure

Summary Current management of N0 stage lip Squamous Cell Carcinoma (SCC) are prophylactic neck dissection, radiotherapy, or “watch and see” policy. The aim is the evaluation of the role of sentinel lymph node biopsy (SLNB) in their management based upon actual and not hypothetical presence of cervic...

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Bibliographic Details
Published in:Oral oncology 2008-06, Vol.44 (6), p.608-612
Main Authors: Khalil, H.H, Elaffandi, A.H, Afifi, A, Alsayed, Y, Mahboub, T, El-Refaie, K.M
Format: Article
Language:English
Subjects:
Adult
Aged
Ambulatory Surgical Procedures
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - surgery
Coloring Agents
Female
Follow-Up Studies
Hematology, Oncology and Palliative Medicine
Humans
Lip Neoplasms - pathology
Lip Neoplasms - surgery
Lymphatic Metastasis - diagnosis
Male
Middle Aged
Otolaryngology
Radiopharmaceuticals
Sentinel Lymph Node Biopsy
Technetium Tc 99m Sulfur Colloid
Treatment Outcome
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Summary:Summary Current management of N0 stage lip Squamous Cell Carcinoma (SCC) are prophylactic neck dissection, radiotherapy, or “watch and see” policy. The aim is the evaluation of the role of sentinel lymph node biopsy (SLNB) in their management based upon actual and not hypothetical presence of cervical lymph node (CLN) micrometastases as a same day procedure. Fourteen patients between November 2003 and August 2005 were included, nine men and five women, median age:57 years, (range 34–65 years). SLNB using preoperative lymphoscintigraphy and intra-operative localisation with patent blue and radioactive Tc99m Human Serum Albumin was performed. The median follow-up period was 26 months. Successful patent blue localisation in 13/14 whilst successful radio-localisation in all patients. Micrometastases were detected in 1/14 whom underwent therapeutic neck dissection. No local recurrence or regional lymph node involvement were detected. SLNB is a technically feasible and accurate approach for detection of CLN micrometastases in N0 stage lip SCC using the triple diagnostic localisation technique as a same day procedure.
ISSN:1368-8375
DOI:10.1016/j.oraloncology.2007.07.002