Coronary flow reserve is also impaired in patients with subclinical hypothyroidism

Abstract The diagnosis of subclinical hypothyroidism and detection of its effects on cardiovascular system is important. Also, the patients with subclinical hypothyroidism even at the very early stage are at increased risk for developing atherosclerosis. We evaluated coronary microvascular circulati...

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Bibliographic Details
Published in:International journal of cardiology 2007-09, Vol.120 (3), p.414-416
Main Authors: Oflaz, Huseyin, Kurt, Ramazan, Cimen, Arif, Elitok, Ali, Onur, Imran, Golcuk, Ebru, Demirturk, Mustafa, Batmaz, Serap, Kasikcioglu, Erdem
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood Flow Velocity - physiology
Cardiology. Vascular system
Cardiovascular
Cardiovascular system
Case-Control Studies
Coronary Circulation - physiology
Coronary flow reserve
Echocardiography
Echocardiography, Doppler
Endocrinopathies
Endothelium, Vascular - diagnostic imaging
Endothelium, Vascular - physiopathology
Female
Homeostasis - physiology
Humans
Hypothyroidism - blood
Hypothyroidism - physiopathology
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Microcirculation - diagnostic imaging
Microcirculation - physiopathology
Middle Aged
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Subclinical hypothyroidism
Thyroid. Thyroid axis (diseases)
Thyrotropin - blood
Thyroxine - blood
Ultrasonic investigative techniques
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Summary:Abstract The diagnosis of subclinical hypothyroidism and detection of its effects on cardiovascular system is important. Also, the patients with subclinical hypothyroidism even at the very early stage are at increased risk for developing atherosclerosis. We evaluated coronary microvascular circulation and endothelial dysfunction of epicardial coronary arteries by the measurement of coronary flow velocity reserve via a non invasive technique, transthoracic Doppler echocardiography in subclinical hypothyroidism. Coronary flow reserve in patients with subclinical hypothyroidism such as in overt hypothyroidism was lower than that of euthyroid subject. As a conclusion, endothelial and microvascular dysfunction, which are early harbingers of atherosclerosis, are shown in overt and subclinical hypothyroidism.
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2006.08.017