Evidence of a specific pancreatic polypeptide receptor in rat arterial smooth muscle

Pancreatic polypeptide (PP) is a member of the PP fold family of regulatory peptides. Studies have shown that neuropeptide Y, peptide YY, and PP increased gastrointestinal motility. The GI effects of neuropeptide Y and peptide YY were accompanied by an increase in mean arterial blood pressure; howev...

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Bibliographic Details
Published in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1999-09, Vol.20 (9), p.1107-1113
Main Authors: Barrios, Victor E, Sun, Jilin, Douglass, Jim, Toombs, Christopher F
Format: Article
Language:English
Subjects:
Animals
Artery
Humans
In Vitro Techniques
Male
Muscle, Smooth, Vascular - metabolism
Neurogenic vasoconstriction
Pancreatic polypeptide
Pancreatic Polypeptide - metabolism
Rats
Rats, Sprague-Dawley
Receptors, Gastrointestinal Hormone - genetics
Receptors, Gastrointestinal Hormone - metabolism
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - genetics
RNA, Messenger - metabolism
Y 4 receptor
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Summary:Pancreatic polypeptide (PP) is a member of the PP fold family of regulatory peptides. Studies have shown that neuropeptide Y, peptide YY, and PP increased gastrointestinal motility. The GI effects of neuropeptide Y and peptide YY were accompanied by an increase in mean arterial blood pressure; however, PP decreased mean arterial blood pressure. Cloning of a receptor of the neuropeptide Y family with high affinity for PP has been reported. This Y 4 receptor is present in intestine, pancreas, and prostate, and its mRNA has been detected in brain and coronary artery. We found in vitro evidence of PP-mediated inhibition of arterial neurogenic vasoconstriction. We have also detected Y 4 mRNA in rat peripheral arteries. These findings suggest a potential role for the Y 4 receptor in regulating vascular tone.
ISSN:0196-9781
1873-5169
DOI:10.1016/S0196-9781(99)00106-0