Functional in vivo assessment of retinal artery microirregularities in glaucoma

Purpose:  We investigated whether retinal branch arteries in healthy subjects, and non‐treated and treated primary open‐angle glaucoma (POAG) patients show irregular local patterns during dynamic reaction to acute increases of different magnitudes in intraocular pressure (IOP). Methods:  Nine POAG p...

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Published in:Acta ophthalmologica (Oxford, England) England), 2008-06, Vol.86 (4), p.424-433
Main Authors: Kotliar, Konstantin E., Nagel, Edgar, Vilser, Walthard, Lanzl, Ines M.
Format: Article
Language:English
Subjects:
Aged
blood flow
Blood Pressure
Female
Glaucoma, Open-Angle - pathology
Glaucoma, Open-Angle - physiopathology
Heart Rate
high‐frequency waviness
Humans
intraocular pressure
Intraocular Pressure - physiology
Male
microirregularities
Middle Aged
Ophthalmodynamometry
primary open‐angle glaucoma
Reaction Time - physiology
Regional Blood Flow
retinal arteries
Retinal Artery - pathology
Retinal Artery - physiology
Vascular Resistance
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Summary:Purpose:  We investigated whether retinal branch arteries in healthy subjects, and non‐treated and treated primary open‐angle glaucoma (POAG) patients show irregular local patterns during dynamic reaction to acute increases of different magnitudes in intraocular pressure (IOP). Methods:  Nine POAG patients and nine age‐matched normal volunteers were examined with the retinal vessel analyser (RVA) using a suprasystolic IOP increase (Study 1). Fourteen POAG patients and 13 age‐matched controls were examined using a moderate IOP increase for 100 seconds (Study 2). Longitudinal arterial profiles were obtained for the chosen time intervals. The high‐frequency waviness (HFW) of these profiles was analysed quantitatively. Results:  No significant changes in HFW were found in controls in different phases of the arterial reaction. Significant increases in HFW from baseline to dilation (Study 1, P 
ISSN:1755-375X
1755-3768
DOI:10.1111/j.1600-0420.2007.01072.x