Signalling, inflammation and arthritis: crossed signals: the role of interleukin (IL)-12, -17, -23 and -27 in autoimmunity

Autoimmune diseases such as rheumatoid arthritis are the consequence of a persistent imbalance between pro- and anti-inflammatory immune mechanisms leading to chronic inflammation. The action of several cytokines is at the basis of this complex process. This review is focused on the signalling event...

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Bibliographic Details
Published in:Rheumatology (Oxford, England) England), 2008-06, Vol.47 (6), p.771-776
Main Authors: Paunovic, V, Carroll, H P, Vandenbroeck, K, Gadina, M
Format: Article
Language:English
Subjects:
Arthritis, Rheumatoid - immunology
Autoimmune Diseases - immunology
Humans
Interleukin-12 - immunology
Interleukin-17 - immunology
Interleukins - immunology
Signal Transduction - immunology
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Summary:Autoimmune diseases such as rheumatoid arthritis are the consequence of a persistent imbalance between pro- and anti-inflammatory immune mechanisms leading to chronic inflammation. The action of several cytokines is at the basis of this complex process. This review is focused on the signalling events triggered by two major groups of cytokines, namely the IL-12 and IL-17 families, which in the past few years have been shown to have a prominent role in the pathogenesis of such diseases. In particular, we will focus on the signalling cascades set in motion by such cytokines and how this may relate to the pathogenesis of human immune and inflammatory disorders as knowledge of such cascades may help in the development of novel therapeutic approaches for such diseases.
ISSN:1462-0324
1462-0332
DOI:10.1093/rheumatology/kem352