Update on non-alcoholic fatty liver disease in children

Summary Non-alcoholic fatty liver disease (NAFLD) is probably the most common cause of liver disease in the pediatric community. It is closely associated with obesity and insulin resistance. NAFLD may lead to non-alcoholic steatohepatitis (NASH). Although NASH is a prerequisite for the definition of...

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Bibliographic Details
Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2007-08, Vol.26 (4), p.409-415
Main Authors: Papandreou, Dimitrios, Rousso, Israel, Mavromichalis, Ioannis
Format: Article
Language:English
Subjects:
Biological and medical sciences
Child
Children
Diagnosis, Differential
Exercise - physiology
Fatty Liver - epidemiology
Fatty Liver - etiology
Fatty Liver - pathology
Fatty Liver - therapy
Gastroenterology and Hepatology
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Insulin Resistance
Liver disease
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Metabolic diseases
Non-alcoholic fatty liver
Obesity
Obesity - complications
Other diseases. Semiology
Public Health
Severity of Illness Index
Steatohepatitis
Weight Loss - physiology
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Summary:Summary Non-alcoholic fatty liver disease (NAFLD) is probably the most common cause of liver disease in the pediatric community. It is closely associated with obesity and insulin resistance. NAFLD may lead to non-alcoholic steatohepatitis (NASH). Although NASH is a prerequisite for the definition of NAFLD in adults and children, distinct differences are often apparent in the extent or location of fat, inflammation and fibrosis. Confirmation of the diagnosis of NAFLD can usually be achieved by imaging studies; however, staging the disease requires a liver biopsy. Current treatment relies on weight loss and exercise, although various insulin-sensitizing agents, antioxidants and medications appear promising. The aim of this review is to summarize what is known about pediatric NAFLD in terms of prevalence, pathogenesis, diagnosis, histology and treatment.
ISSN:0261-5614
1532-1983
DOI:10.1016/j.clnu.2007.02.002