Anti-ulcer actions of the bark methanol extract of Voacanga africana in different experimental ulcer models in rats

The antiulcerogenic effects of the bark methanol extract of Voacanga africana were studied using various experimental ulcer models in rats. The effects of the extract on the volume of gastric juice, gastric pH, acid output, mucus production and peptic activity were recorded, as well as the preventiv...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2000-12, Vol.73 (3), p.423-428
Main Authors: Tan, Paul V, Penlap, Veronique B, Nyasse, Barthelemy, Nguemo, Joseph D.B
Format: Article
Language:English
Subjects:
Animals
Anti-ulcer activity
Anti-Ulcer Agents - pharmacology
Apocynaceae
Bark methanol extract
Biological and medical sciences
Disease Models, Animal
General pharmacology
Magnoliopsida - chemistry
Male
Medical sciences
Methanol - chemistry
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - pharmacology
Rats
Rats, Wistar
Voacanga africana
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Summary:The antiulcerogenic effects of the bark methanol extract of Voacanga africana were studied using various experimental ulcer models in rats. The effects of the extract on the volume of gastric juice, gastric pH, acid output, mucus production and peptic activity were recorded, as well as the preventive action against lesions caused by HCl/ethanol and indomethacin. Oral administration of the extract (500–750 mg/kg) inhibited the formation of gastric lesions induced by HCl/ethanol (40–63% inhibition). The inhibitory effect against HCl/ethanol was significantly ( P
ISSN:0378-8741
1872-7573
DOI:10.1016/S0378-8741(00)00292-0