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Computer-assisted validation of the synovitis score
Histopathological examination of synovial specimens can contribute to the diagnosis of chronic joint diseases. A so-called synovitis score has been introduced as a standardised grading system, based on the semi-quantitative evaluation of the three determining features of chronic synovitis: enlargeme...
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| Published in: | Virchows Archiv : an international journal of pathology 2008-06, Vol.452 (6), p.667-673 |
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| cites | cdi_FETCH-LOGICAL-c399t-582fb26c3f277fcadd3f50f88dcc73ec69036113225f660a8a3701029492a79e3 |
| container_end_page | 673 |
| container_issue | 6 |
| container_start_page | 667 |
| container_title | Virchows Archiv : an international journal of pathology |
| container_volume | 452 |
| creator | Morawietz, Lars Schaeper, Frank Schroeder, Joerg H. Gansukh, Tserenchunt Baasanjav, Nachin Krukemeyer, Manfred G. Gehrke, Thorsten Krenn, Veit |
| description | Histopathological examination of synovial specimens can contribute to the diagnosis of chronic joint diseases. A so-called synovitis score has been introduced as a standardised grading system, based on the semi-quantitative evaluation of the three determining features of chronic synovitis: enlargement of synovial lining, density of synovial stroma and inflammatory infiltrate, giving a score between 0 and 9. The present study examines the reliability of this procedure by comparison with exact measurements using computer-assisted image analysis (CAIA). Seventy-one synovial specimens from patients with osteoarthritis (OA,
n
= 22), psoriatic arthritis (PsA,
n
= 7), rheumatoid arthritis (RA,
n
= 35) and from a control group (Co,
n
= 7) were evaluated using both the synovitis score and CAIA. The measurements were transformed to semi-quantitative values analogous to the synovitis score. The differences between the transformed CAIA scores and the pathologist’s scores were 0 or +/−1 in 40 cases, whereas in 31 cases the difference was greater than 1 (correlation coefficient
r
= 0.725). The CAIA scores differed significantly between Co and RA cases (
p
= 0.000) as well as between OA and RA (
p
= 0.000). We conclude that the synovitis score was validated by CAIA and can be regarded a reliable grading system that contributes to the diagnostic procedure of chronic joint inflammation. |
| doi_str_mv | 10.1007/s00428-008-0587-8 |
| format | article |
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n
= 22), psoriatic arthritis (PsA,
n
= 7), rheumatoid arthritis (RA,
n
= 35) and from a control group (Co,
n
= 7) were evaluated using both the synovitis score and CAIA. The measurements were transformed to semi-quantitative values analogous to the synovitis score. The differences between the transformed CAIA scores and the pathologist’s scores were 0 or +/−1 in 40 cases, whereas in 31 cases the difference was greater than 1 (correlation coefficient
r
= 0.725). The CAIA scores differed significantly between Co and RA cases (
p
= 0.000) as well as between OA and RA (
p
= 0.000). We conclude that the synovitis score was validated by CAIA and can be regarded a reliable grading system that contributes to the diagnostic procedure of chronic joint inflammation.</description><identifier>ISSN: 0945-6317</identifier><identifier>EISSN: 1432-2307</identifier><identifier>DOI: 10.1007/s00428-008-0587-8</identifier><identifier>PMID: 18283490</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Arthritis, Psoriatic - pathology ; Arthritis, Rheumatoid - pathology ; Biological and medical sciences ; Chronic Disease ; Correlation coefficient ; Diseases of the osteoarticular system ; Humans ; Image Processing, Computer-Assisted ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; Medicine ; Medicine & Public Health ; Miscellaneous. Osteoarticular involvement in other diseases ; Observer Variation ; Original Article ; Osteoarthritis ; Osteoarthritis - pathology ; Pathology ; Pathology, Clinical - methods ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Rheumatoid arthritis ; Synovial Membrane - pathology ; Synovitis - classification ; Synovitis - pathology</subject><ispartof>Virchows Archiv : an international journal of pathology, 2008-06, Vol.452 (6), p.667-673</ispartof><rights>Springer-Verlag 2008</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-582fb26c3f277fcadd3f50f88dcc73ec69036113225f660a8a3701029492a79e3</citedby><cites>FETCH-LOGICAL-c399t-582fb26c3f277fcadd3f50f88dcc73ec69036113225f660a8a3701029492a79e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20400450$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18283490$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morawietz, Lars</creatorcontrib><creatorcontrib>Schaeper, Frank</creatorcontrib><creatorcontrib>Schroeder, Joerg H.</creatorcontrib><creatorcontrib>Gansukh, Tserenchunt</creatorcontrib><creatorcontrib>Baasanjav, Nachin</creatorcontrib><creatorcontrib>Krukemeyer, Manfred G.</creatorcontrib><creatorcontrib>Gehrke, Thorsten</creatorcontrib><creatorcontrib>Krenn, Veit</creatorcontrib><title>Computer-assisted validation of the synovitis score</title><title>Virchows Archiv : an international journal of pathology</title><addtitle>Virchows Arch</addtitle><addtitle>Virchows Arch</addtitle><description>Histopathological examination of synovial specimens can contribute to the diagnosis of chronic joint diseases. A so-called synovitis score has been introduced as a standardised grading system, based on the semi-quantitative evaluation of the three determining features of chronic synovitis: enlargement of synovial lining, density of synovial stroma and inflammatory infiltrate, giving a score between 0 and 9. The present study examines the reliability of this procedure by comparison with exact measurements using computer-assisted image analysis (CAIA). Seventy-one synovial specimens from patients with osteoarthritis (OA,
n
= 22), psoriatic arthritis (PsA,
n
= 7), rheumatoid arthritis (RA,
n
= 35) and from a control group (Co,
n
= 7) were evaluated using both the synovitis score and CAIA. The measurements were transformed to semi-quantitative values analogous to the synovitis score. The differences between the transformed CAIA scores and the pathologist’s scores were 0 or +/−1 in 40 cases, whereas in 31 cases the difference was greater than 1 (correlation coefficient
r
= 0.725). The CAIA scores differed significantly between Co and RA cases (
p
= 0.000) as well as between OA and RA (
p
= 0.000). We conclude that the synovitis score was validated by CAIA and can be regarded a reliable grading system that contributes to the diagnostic procedure of chronic joint inflammation.</description><subject>Arthritis, Psoriatic - pathology</subject><subject>Arthritis, Rheumatoid - pathology</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>Correlation coefficient</subject><subject>Diseases of the osteoarticular system</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Miscellaneous. Osteoarticular involvement in other diseases</subject><subject>Observer Variation</subject><subject>Original Article</subject><subject>Osteoarthritis</subject><subject>Osteoarthritis - pathology</subject><subject>Pathology</subject><subject>Pathology, Clinical - methods</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Rheumatoid arthritis</subject><subject>Synovial Membrane - pathology</subject><subject>Synovitis - classification</subject><subject>Synovitis - pathology</subject><issn>0945-6317</issn><issn>1432-2307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNp1kE1LAzEQhoMotlZ_gBdZBL2tTpLdTXKU4hcUvOg5pNlEt2w3NbNb6L83pcWC4GGYwzzzzvAQcknhjgKIewQomMwBUpVS5PKIjGnBWc44iGMyBlWUecWpGJEzxAUAo5JWp2REJZO8UDAmfBqWq6F3MTeIDfauztambWrTN6HLgs_6L5fhpgvrpm8wQxuiOycn3rToLvZ9Qj6eHt-nL_ns7fl1-jDLLVeqz0vJ_JxVlnsmhLemrrkvwUtZWyu4s5UCXlHKGSt9VYGRhgugwFShmBHK8Qm53eWuYvgeHPZ62aB1bWs6FwbUAoQoQYoEXv8BF2GIXfpNMwalUMlWgugOsjEgRuf1KjZLEzeagt7q1DudOunUW51app2rffAwX7r6sLH3l4CbPWDQmtZH09kGfzkGRcostxzbcZhG3aeLhw__v_4Df3eK2Q</recordid><startdate>20080601</startdate><enddate>20080601</enddate><creator>Morawietz, Lars</creator><creator>Schaeper, Frank</creator><creator>Schroeder, Joerg H.</creator><creator>Gansukh, Tserenchunt</creator><creator>Baasanjav, Nachin</creator><creator>Krukemeyer, Manfred G.</creator><creator>Gehrke, Thorsten</creator><creator>Krenn, Veit</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20080601</creationdate><title>Computer-assisted validation of the synovitis score</title><author>Morawietz, Lars ; Schaeper, Frank ; Schroeder, Joerg H. ; Gansukh, Tserenchunt ; Baasanjav, Nachin ; Krukemeyer, Manfred G. ; Gehrke, Thorsten ; Krenn, Veit</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-582fb26c3f277fcadd3f50f88dcc73ec69036113225f660a8a3701029492a79e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Arthritis, Psoriatic - pathology</topic><topic>Arthritis, Rheumatoid - pathology</topic><topic>Biological and medical sciences</topic><topic>Chronic Disease</topic><topic>Correlation coefficient</topic><topic>Diseases of the osteoarticular system</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Miscellaneous. Osteoarticular involvement in other diseases</topic><topic>Observer Variation</topic><topic>Original Article</topic><topic>Osteoarthritis</topic><topic>Osteoarthritis - pathology</topic><topic>Pathology</topic><topic>Pathology, Clinical - methods</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. 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A so-called synovitis score has been introduced as a standardised grading system, based on the semi-quantitative evaluation of the three determining features of chronic synovitis: enlargement of synovial lining, density of synovial stroma and inflammatory infiltrate, giving a score between 0 and 9. The present study examines the reliability of this procedure by comparison with exact measurements using computer-assisted image analysis (CAIA). Seventy-one synovial specimens from patients with osteoarthritis (OA,
n
= 22), psoriatic arthritis (PsA,
n
= 7), rheumatoid arthritis (RA,
n
= 35) and from a control group (Co,
n
= 7) were evaluated using both the synovitis score and CAIA. The measurements were transformed to semi-quantitative values analogous to the synovitis score. The differences between the transformed CAIA scores and the pathologist’s scores were 0 or +/−1 in 40 cases, whereas in 31 cases the difference was greater than 1 (correlation coefficient
r
= 0.725). The CAIA scores differed significantly between Co and RA cases (
p
= 0.000) as well as between OA and RA (
p
= 0.000). We conclude that the synovitis score was validated by CAIA and can be regarded a reliable grading system that contributes to the diagnostic procedure of chronic joint inflammation.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>18283490</pmid><doi>10.1007/s00428-008-0587-8</doi><tpages>7</tpages></addata></record> |
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| subjects | Arthritis, Psoriatic - pathology Arthritis, Rheumatoid - pathology Biological and medical sciences Chronic Disease Correlation coefficient Diseases of the osteoarticular system Humans Image Processing, Computer-Assisted Investigative techniques, diagnostic techniques (general aspects) Medical sciences Medicine Medicine & Public Health Miscellaneous. Osteoarticular involvement in other diseases Observer Variation Original Article Osteoarthritis Osteoarthritis - pathology Pathology Pathology, Clinical - methods Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Rheumatoid arthritis Synovial Membrane - pathology Synovitis - classification Synovitis - pathology |
| title | Computer-assisted validation of the synovitis score |
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