Influence of L-thyroxine therapy on parathyroid hormone concentrations

In our RIA laboratory, we serendipitously observed that an unusual number of patients referred from the outpatient endocrinology clinic of the St. Savas Oncology Hospital had parathyroid hormone (PTH) concentrations exceeding the recommended upper reference limit of 6.90 pmol/L (65 ng/L) of our assa...

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Bibliographic Details
Published in:Clinical chemistry (Baltimore, Md.) Md.), 2008-06, Vol.54 (6), p.1092-1093
Main Authors: Zanglis, Adonios, Andreopoulos, Demetrios, Baziotis, Nikolaos
Format: Article
Language:English
Subjects:
Adult
Aged
Drug therapy
Female
Goiter - drug therapy
Hormones
Hospitals
Humans
Hypothyroidism
Hypothyroidism - drug therapy
Kinases
Male
Middle Aged
Parathyroid Hormone - blood
Plasma
Thyroid gland
Thyroid Neoplasms - drug therapy
Thyroiditis - drug therapy
Thyrotropin - blood
Thyroxine - therapeutic use
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Summary:In our RIA laboratory, we serendipitously observed that an unusual number of patients referred from the outpatient endocrinology clinic of the St. Savas Oncology Hospital had parathyroid hormone (PTH) concentrations exceeding the recommended upper reference limit of 6.90 pmol/L (65 ng/L) of our assay (ELSA-PTH, Cisbio International). The findings in this report could be attributable to a nongenomic action of the supraphysiological peak L-thyroxine concentrations on the parathyroid cells, possibly via mitogen-activated protein kinase, bypassing the calcium-sensing receptor regulation (4).
ISSN:0009-9147
1530-8561
DOI:10.1373/clinchem.2007.102194