Psychosocial job characteristics and plasma fibrinogen in Japanese male and female workers: the Jichi Medical School cohort study

Abstract The aim of the study was to explore the association between psychosocial job characteristics and plasma fibrinogen levels among 1588 male and 1677 female Japanese workers aged 65 and younger. Sociodemographic and behavioral variables were obtained by a standardized questionnaire, which incl...

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Bibliographic Details
Published in:Atherosclerosis 2008-06, Vol.198 (2), p.468-476
Main Authors: Hirokawa, Kumi, Tsutsumi, Akizumi, Kayaba, Kazunori
Format: Article
Language:English
Subjects:
Adult
Aged
Asian Continental Ancestry Group
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Cardiovascular
Cardiovascular Diseases - etiology
Cohort Studies
Coronary heart disease
Female
Fibrinogen
Fibrinogen - analysis
Gender difference
Heart
Humans
Japan
Japanese worker
Job control
Job demand
Job Description
Job strain
Male
Medical sciences
Middle Aged
Occupations
Stress, Psychological - blood
Stress, Psychological - complications
Stress, Psychological - psychology
Workload - psychology
Workplace - psychology
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Summary:Abstract The aim of the study was to explore the association between psychosocial job characteristics and plasma fibrinogen levels among 1588 male and 1677 female Japanese workers aged 65 and younger. Sociodemographic and behavioral variables were obtained by a standardized questionnaire, which included the Japanese version of the demand–control questionnaire. Fibrinogen levels were determined with a one-stage clotting assay kit. Job strain – a ratio of demand to control – was positively associated with plasma fibrinogen ( p for trend < 0.05) but ANCOVA showed that the main effect was only marginally statistically significant in men. Analyses by individual job characteristics components revealed that men with a high level of job demand (Age-adjusted geometric mean (mg/dl) = 234.6, 95% CI: 230.9–238.2) showed a higher fibrinogen level than those with other levels (middle; 227.9, 223.6–232.3, low; 224.8, 220.5–229.1) (F (2, 1584) = 6.63, p < 0.001). Adjustment for potential confounders including total cholesterol and CRP did not reduce the association. No significant association was found between psychosocial job characteristics and fibrinogen in women. The findings appear to imply a mechanism through which adverse psychosocial job characteristics lead to cardiovascular diseases in men.
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2007.09.035