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Primary peritoneal serous papillary carcinoma: clinical and laboratory characteristics
Background Primary peritoneal papillary serous carcinoma (PPPSC) is an uncommon primary malignancy of the peritoneum. The aim of our study is to present the characteristics of such a rare entity through our case series. Method This is a retrospective study of nine cases of PPPSC who were treated bet...
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Published in: | Archives of gynecology and obstetrics 2008-07, Vol.278 (1), p.53-56 |
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container_title | Archives of gynecology and obstetrics |
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creator | Iavazzo, C. Vorgias, G. Katsoulis, M. Kalinoglou, N. Dertimas, V. Akrivos, T. |
description | Background
Primary peritoneal papillary serous carcinoma (PPPSC) is an uncommon primary malignancy of the peritoneum. The aim of our study is to present the characteristics of such a rare entity through our case series.
Method
This is a retrospective study of nine cases of PPPSC who were treated between January 2002 and April 2007 in METAXA Memorial Cancer Hospital, Piraeus, Greece. Medical files and histopathological diagnosis of each patient were retrospectively studied.
Results
The median age of the patients was 63 years ranging from 44 up to 74 years. Clinically PPPSC presented with general abdominal discomfort in all of the patients. Three out of nine patients presented with constipation, 5/9 with distention, and 7/9 with ascites. All of the patients referred loss of appetite with weight gaining due to ascites. All the patients had pathological values of CA125 (over 35 U/ml) ranging from 125 up to 1,255 U/ml with median value 565 U/ml. Optimal debulking was possible in 3/9 of patients who were consequently treated with standard taxol-platin chemotherapy. Complete response was achieved in one woman. The median disease-free survival was 7 months and the median overall survival rate was 2.5 years.
Conclusion
PPPSC mimics ovarian papillary serous carcinoma regarding the clinical and laboratory characteristics but it has worse prognosis. |
doi_str_mv | 10.1007/s00404-008-0678-4 |
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Primary peritoneal papillary serous carcinoma (PPPSC) is an uncommon primary malignancy of the peritoneum. The aim of our study is to present the characteristics of such a rare entity through our case series.
Method
This is a retrospective study of nine cases of PPPSC who were treated between January 2002 and April 2007 in METAXA Memorial Cancer Hospital, Piraeus, Greece. Medical files and histopathological diagnosis of each patient were retrospectively studied.
Results
The median age of the patients was 63 years ranging from 44 up to 74 years. Clinically PPPSC presented with general abdominal discomfort in all of the patients. Three out of nine patients presented with constipation, 5/9 with distention, and 7/9 with ascites. All of the patients referred loss of appetite with weight gaining due to ascites. All the patients had pathological values of CA125 (over 35 U/ml) ranging from 125 up to 1,255 U/ml with median value 565 U/ml. Optimal debulking was possible in 3/9 of patients who were consequently treated with standard taxol-platin chemotherapy. Complete response was achieved in one woman. The median disease-free survival was 7 months and the median overall survival rate was 2.5 years.
Conclusion
PPPSC mimics ovarian papillary serous carcinoma regarding the clinical and laboratory characteristics but it has worse prognosis.</description><identifier>ISSN: 0932-0067</identifier><identifier>EISSN: 1432-0711</identifier><identifier>DOI: 10.1007/s00404-008-0678-4</identifier><identifier>PMID: 18488238</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Appetite ; Ascites - etiology ; CA-125 Antigen - blood ; Carboplatin - administration & dosage ; Cisplatin - administration & dosage ; Constipation - etiology ; Cystadenocarcinoma, Serous - mortality ; Cystadenocarcinoma, Serous - pathology ; Cystadenocarcinoma, Serous - therapy ; Endocrinology ; Female ; Gynecologic Surgical Procedures ; Gynecology ; Human Genetics ; Humans ; Laboratories ; Medical prognosis ; Medicine ; Medicine & Public Health ; Middle Aged ; Obstetrics/Perinatology/Midwifery ; Paclitaxel - administration & dosage ; Peritoneal Neoplasms - mortality ; Peritoneal Neoplasms - pathology ; Peritoneal Neoplasms - therapy ; Retrospective Studies ; Short Communication ; Weight Gain</subject><ispartof>Archives of gynecology and obstetrics, 2008-07, Vol.278 (1), p.53-56</ispartof><rights>Springer-Verlag 2008</rights><rights>Archives of Gynecology and Obstetrics is a copyright of Springer, (2008). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-52df7f0faa0b9091705bd71024ca08833490b623ed0470fedf648dd54fe415b03</citedby><cites>FETCH-LOGICAL-c436t-52df7f0faa0b9091705bd71024ca08833490b623ed0470fedf648dd54fe415b03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18488238$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iavazzo, C.</creatorcontrib><creatorcontrib>Vorgias, G.</creatorcontrib><creatorcontrib>Katsoulis, M.</creatorcontrib><creatorcontrib>Kalinoglou, N.</creatorcontrib><creatorcontrib>Dertimas, V.</creatorcontrib><creatorcontrib>Akrivos, T.</creatorcontrib><title>Primary peritoneal serous papillary carcinoma: clinical and laboratory characteristics</title><title>Archives of gynecology and obstetrics</title><addtitle>Arch Gynecol Obstet</addtitle><addtitle>Arch Gynecol Obstet</addtitle><description>Background
Primary peritoneal papillary serous carcinoma (PPPSC) is an uncommon primary malignancy of the peritoneum. The aim of our study is to present the characteristics of such a rare entity through our case series.
Method
This is a retrospective study of nine cases of PPPSC who were treated between January 2002 and April 2007 in METAXA Memorial Cancer Hospital, Piraeus, Greece. Medical files and histopathological diagnosis of each patient were retrospectively studied.
Results
The median age of the patients was 63 years ranging from 44 up to 74 years. Clinically PPPSC presented with general abdominal discomfort in all of the patients. Three out of nine patients presented with constipation, 5/9 with distention, and 7/9 with ascites. All of the patients referred loss of appetite with weight gaining due to ascites. All the patients had pathological values of CA125 (over 35 U/ml) ranging from 125 up to 1,255 U/ml with median value 565 U/ml. Optimal debulking was possible in 3/9 of patients who were consequently treated with standard taxol-platin chemotherapy. Complete response was achieved in one woman. The median disease-free survival was 7 months and the median overall survival rate was 2.5 years.
Conclusion
PPPSC mimics ovarian papillary serous carcinoma regarding the clinical and laboratory characteristics but it has worse prognosis.</description><subject>Adult</subject><subject>Aged</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Appetite</subject><subject>Ascites - etiology</subject><subject>CA-125 Antigen - blood</subject><subject>Carboplatin - administration & dosage</subject><subject>Cisplatin - administration & dosage</subject><subject>Constipation - etiology</subject><subject>Cystadenocarcinoma, Serous - mortality</subject><subject>Cystadenocarcinoma, Serous - pathology</subject><subject>Cystadenocarcinoma, Serous - therapy</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Gynecologic Surgical Procedures</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Paclitaxel - administration & dosage</subject><subject>Peritoneal Neoplasms - mortality</subject><subject>Peritoneal Neoplasms - pathology</subject><subject>Peritoneal Neoplasms - therapy</subject><subject>Retrospective Studies</subject><subject>Short Communication</subject><subject>Weight Gain</subject><issn>0932-0067</issn><issn>1432-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNp1kM1KxDAURoMozjj6AG6kILir3qRpk7qTwT8Y0IW6DWmaaIa2qUm78O1N6cCA4CqB79wvNwehcwzXGIDdBAAKNAXgKRSMp_QALTHNSAoM40O0hHK6x2iBTkLYAmDCeXGMFphTzknGl-jj1dtW-p-k194OrtOySYL2bgxJL3vbNFOmpFe2c628TVRjO6siJLs6aWTlvBzchHxJL9UQS8JgVThFR0Y2QZ_tzhV6f7h_Wz-lm5fH5_XdJlU0K4Y0J7VhBoyUUJVQYgZ5VTMMhCoJnGcZLaEqSKZroAyMrk1BeV3n1GiK8wqyFbqae3vvvkcdBtHaoHRcu9PxD4IBY6zEZQQv_4BbN_ou7iYIKTAvCQUWKTxTyrsQvDain_UIDGJSLmblIioXk3JB48zFrnmsWl3vJ3aOI0BmIMSo-9R-__T_rb_dW4xV</recordid><startdate>20080701</startdate><enddate>20080701</enddate><creator>Iavazzo, C.</creator><creator>Vorgias, G.</creator><creator>Katsoulis, M.</creator><creator>Kalinoglou, N.</creator><creator>Dertimas, V.</creator><creator>Akrivos, T.</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20080701</creationdate><title>Primary peritoneal serous papillary carcinoma: clinical and laboratory characteristics</title><author>Iavazzo, C. ; Vorgias, G. ; Katsoulis, M. ; Kalinoglou, N. ; Dertimas, V. ; Akrivos, T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-52df7f0faa0b9091705bd71024ca08833490b623ed0470fedf648dd54fe415b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Appetite</topic><topic>Ascites - etiology</topic><topic>CA-125 Antigen - blood</topic><topic>Carboplatin - administration & dosage</topic><topic>Cisplatin - administration & dosage</topic><topic>Constipation - etiology</topic><topic>Cystadenocarcinoma, Serous - mortality</topic><topic>Cystadenocarcinoma, Serous - pathology</topic><topic>Cystadenocarcinoma, Serous - therapy</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Gynecologic Surgical Procedures</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Laboratories</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Paclitaxel - administration & dosage</topic><topic>Peritoneal Neoplasms - mortality</topic><topic>Peritoneal Neoplasms - pathology</topic><topic>Peritoneal Neoplasms - therapy</topic><topic>Retrospective Studies</topic><topic>Short Communication</topic><topic>Weight Gain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iavazzo, C.</creatorcontrib><creatorcontrib>Vorgias, G.</creatorcontrib><creatorcontrib>Katsoulis, M.</creatorcontrib><creatorcontrib>Kalinoglou, N.</creatorcontrib><creatorcontrib>Dertimas, V.</creatorcontrib><creatorcontrib>Akrivos, T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iavazzo, C.</au><au>Vorgias, G.</au><au>Katsoulis, M.</au><au>Kalinoglou, N.</au><au>Dertimas, V.</au><au>Akrivos, T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Primary peritoneal serous papillary carcinoma: clinical and laboratory characteristics</atitle><jtitle>Archives of gynecology and obstetrics</jtitle><stitle>Arch Gynecol Obstet</stitle><addtitle>Arch Gynecol Obstet</addtitle><date>2008-07-01</date><risdate>2008</risdate><volume>278</volume><issue>1</issue><spage>53</spage><epage>56</epage><pages>53-56</pages><issn>0932-0067</issn><eissn>1432-0711</eissn><abstract>Background
Primary peritoneal papillary serous carcinoma (PPPSC) is an uncommon primary malignancy of the peritoneum. The aim of our study is to present the characteristics of such a rare entity through our case series.
Method
This is a retrospective study of nine cases of PPPSC who were treated between January 2002 and April 2007 in METAXA Memorial Cancer Hospital, Piraeus, Greece. Medical files and histopathological diagnosis of each patient were retrospectively studied.
Results
The median age of the patients was 63 years ranging from 44 up to 74 years. Clinically PPPSC presented with general abdominal discomfort in all of the patients. Three out of nine patients presented with constipation, 5/9 with distention, and 7/9 with ascites. All of the patients referred loss of appetite with weight gaining due to ascites. All the patients had pathological values of CA125 (over 35 U/ml) ranging from 125 up to 1,255 U/ml with median value 565 U/ml. Optimal debulking was possible in 3/9 of patients who were consequently treated with standard taxol-platin chemotherapy. Complete response was achieved in one woman. The median disease-free survival was 7 months and the median overall survival rate was 2.5 years.
Conclusion
PPPSC mimics ovarian papillary serous carcinoma regarding the clinical and laboratory characteristics but it has worse prognosis.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>18488238</pmid><doi>10.1007/s00404-008-0678-4</doi><tpages>4</tpages></addata></record> |
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subjects | Adult Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Appetite Ascites - etiology CA-125 Antigen - blood Carboplatin - administration & dosage Cisplatin - administration & dosage Constipation - etiology Cystadenocarcinoma, Serous - mortality Cystadenocarcinoma, Serous - pathology Cystadenocarcinoma, Serous - therapy Endocrinology Female Gynecologic Surgical Procedures Gynecology Human Genetics Humans Laboratories Medical prognosis Medicine Medicine & Public Health Middle Aged Obstetrics/Perinatology/Midwifery Paclitaxel - administration & dosage Peritoneal Neoplasms - mortality Peritoneal Neoplasms - pathology Peritoneal Neoplasms - therapy Retrospective Studies Short Communication Weight Gain |
title | Primary peritoneal serous papillary carcinoma: clinical and laboratory characteristics |
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