Regional and temporal progression of reactive astrocytosis in the brain of the myelin mutant taiep rat

Reactive astrocytosis in taiep rats was shown by glial fibrillary acidic protein (GFAP) immunoreactivity measured by means of enzyme-linked immunosorbent assay and indirect immunofluorescence. Increased GFAP immunoreactivity was first observed in the brainstem of 15-day-old taiep rats and was widesp...

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Bibliographic Details
Published in:Brain research 2001-05, Vol.900 (1), p.152-155
Main Authors: Leon Chavez, Bertha A, Guevara, Jorge, Galindo, Silvia, Luna, José, Ugarte, Araceli, Villegas, Olga, Mena, Raúl, Eguibar, José R, Martinez-Fong, Daniel
Format: Article
Language:English
Subjects:
Animals
Astrocytes - chemistry
Astrocytes - pathology
Astrogliosis
Ataxia - genetics
Biological and medical sciences
Biomarkers
Brain - pathology
Demyelinating Diseases - genetics
Demyelinating Diseases - pathology
Demyelination
Disease Progression
Dysmyelination
Endoplasmic Reticulum, Smooth - pathology
Enzyme-Linked Immunosorbent Assay
Epilepsy, Reflex - genetics
Fluorescent Antibody Technique, Indirect
Fundamental and applied biological sciences. Psychology
Glial fibrillary acidic protein
Glial Fibrillary Acidic Protein - analysis
Gliosis - genetics
Gliosis - pathology
Hypertrophy
Isolated neuron and nerve. Neuroglia
Microtubules - pathology
Rats
Rats, Mutant Strains
Rats, Sprague-Dawley
Seizures - genetics
Tremor - genetics
Vertebrates: nervous system and sense organs
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Summary:Reactive astrocytosis in taiep rats was shown by glial fibrillary acidic protein (GFAP) immunoreactivity measured by means of enzyme-linked immunosorbent assay and indirect immunofluorescence. Increased GFAP immunoreactivity was first observed in the brainstem of 15-day-old taiep rats and was widespread throughout all brain regions at 6 months of age. Characteristically, astrocytes were hypertrophic and displayed strong GFAP fluorescence. The pattern of these reactive cells may correlate with the process of dysmyelination in the taiep rat.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(01)02284-3