High serological response to pneumococcal vaccine in nephrotic children at disease onset on high-dose prednisone

Our objective was to demonstrate that nephrotic children at disease onset and under high-dose prednisone respond to vaccination with 23-valent pneumococcal vaccine (PV). We compared the serological response after PV in 30 children with nephrotic syndrome, directly after initiation of prednisone ther...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2008-07, Vol.23 (7), p.1107-1113
Main Authors: Ulinski, Tim, Leroy, Sandrine, Dubrel, Marie, Danon, Sylvie, Bensman, Albert
Format: Article
Language:English
Subjects:
Administration, Oral
Adolescent
Antibodies, Bacterial - blood
Child
Child, Preschool
Drug Resistance
Female
Glucocorticoids - administration & dosage
Humans
Male
Medicine & Public Health
Nephrology
Nephrosis - drug therapy
Nephrosis - immunology
Original Article
Pediatrics
Pneumococcal Vaccines - immunology
Prednisone - administration & dosage
Prospective Studies
Recurrence
Streptococcus pneumoniae
Time Factors
Treatment Outcome
Urology
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Summary:Our objective was to demonstrate that nephrotic children at disease onset and under high-dose prednisone respond to vaccination with 23-valent pneumococcal vaccine (PV). We compared the serological response after PV in 30 children with nephrotic syndrome, directly after initiation of prednisone therapy (60 mg/m 2 body surface area) at disease onset (group 1), with the response in 13 patients who received the vaccine while in remission (group 2). Safety was studied, comparing disease course in group 1 with those in patients who did not receive any PV (group 3). In group 1, 23-valent PV antibody (Ab) levels increased tenfold after 1 month and remained increased after 1 year ( P  
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-008-0782-5