Differential Effects of Drug-Eluting Stents on Local Endothelium-Dependent Coronary Vasomotion

Differential Effects of Drug-Eluting Stents on Local Endothelium-Dependent Coronary Vasomotion Michalis I. Hamilos, Miodrag Ostojic, Branko Beleslin, Dragan Sagic, Ljubco Mangovski, Sinisa Stojkovic, Milan Nedeljkovic, Dejan Orlic, Bratislav Milosavljevic, Dragan Topic, Nevena Karanovic, William Wij...

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Published in:Journal of the American College of Cardiology 2008-06, Vol.51 (22), p.2123-2129
Main Authors: Hamilos, Michalis I., MD, Ostojic, Miodrag, MD, PhD, Beleslin, Branko, MD, PhD, Sagic, Dragan, MD, PhD, Mangovski, Ljubco, MD, Stojkovic, Sinisa, MD, PhD, Nedeljkovic, Milan, MD, PhD, Orlic, Dejan, MD, Milosavljevic, Bratislav, MD, Topic, Dragan, MD, Karanovic, Nevena, MD, PhD, Wijns, William, MD, PhD
Format: Article
Language:English
Subjects:
Cardiology
Cardiovascular
Cardiovascular disease
Coronary Angiography
Coronary vessels
Coronary Vessels - drug effects
Coronary Vessels - physiopathology
Drug-Eluting Stents
Endothelium
Endothelium, Vascular - drug effects
Endothelium, Vascular - physiopathology
Female
Heart
Heart rate
Hemodynamics
Humans
Immunosuppressive Agents - pharmacology
Immunosuppressive Agents - therapeutic use
Internal Medicine
Intubation
Male
Medical imaging
Middle Aged
Paclitaxel - pharmacology
Paclitaxel - therapeutic use
Prospective Studies
Sirolimus - analogs & derivatives
Sirolimus - pharmacology
Sirolimus - therapeutic use
Stents
Vasoconstriction - drug effects
Vasodilation - drug effects
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Summary:Differential Effects of Drug-Eluting Stents on Local Endothelium-Dependent Coronary Vasomotion Michalis I. Hamilos, Miodrag Ostojic, Branko Beleslin, Dragan Sagic, Ljubco Mangovski, Sinisa Stojkovic, Milan Nedeljkovic, Dejan Orlic, Bratislav Milosavljevic, Dragan Topic, Nevena Karanovic, William Wijns, on behalf of the NOBORI CORE Investigators In the present study we compared coronary vasomotion after implantation of biolimus A9-eluting stents (BES) (n = 19) and sirolimus-eluting stents (SES) (n = 15) 9 months after stent implantation. Endothelium-dependent and -independent coronary vasomotion were tested proximally and distally to the stent as well as at a reference segment. Patients with SES showed vasoconstriction in segments proximal and distal to the stent, whereas patients with BES showed vasodilatation. These results are indicative of preserved endothelial function after BES implantation.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2007.12.059