Alpha-2-macroglobulin intronic polymorphism is not associated with autopsy-confirmed late-onset Alzheimer's disease

Alpha-2-macroglobulin (A2M) intronic polymorphism has recently been reported to be associated with late-onset Alzheimer's disease (LOAD). To corroborate this association, we analysed the A2M and apolipoprotein E (APOE) polymorphisms in autopsy cases of the MRC Alzheimer's Disease Brain Ban...

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Bibliographic Details
Published in:Neuroscience letters 1999-09, Vol.273 (1), p.61-63
Main Authors: Kovács, Tibor, Cairns, Nigel J., Lantos, Peter L.
Format: Article
Language:English
Subjects:
a2-Macroglobulin
Age of Onset
Aged
Alleles
Alpha-2 macroglobulin
alpha-Macroglobulins - genetics
Alzheimer Disease - genetics
Alzheimer's disease
Apolipoprotein E
Apolipoproteins E - genetics
Autopsy
Biological and medical sciences
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
DNA Primers
Female
Gene Frequency
Genotype
Humans
Male
Medical sciences
Neurology
Polymorphism, Genetic - genetics
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Summary:Alpha-2-macroglobulin (A2M) intronic polymorphism has recently been reported to be associated with late-onset Alzheimer's disease (LOAD). To corroborate this association, we analysed the A2M and apolipoprotein E (APOE) polymorphisms in autopsy cases of the MRC Alzheimer's Disease Brain Bank, Institute of Psychiatry, London. The frequencies of the insertion and deletion alleles in AD were 0.81 and 0.19, respectively, and these were not significantly different from control frequencies. After pooling the AD cases in ε4 positive and negative subgroups, there was again no significant difference between the A2M allele frequency in the two subgroups. In our present study, we were unable to corroborate the association between A2M intronic polymorphism and LOAD in autopsy cases.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(99)00604-7