Axolotl MHC architecture and polymorphism

The MHC of the urodele amphibian Ambystoma mexicanum consists of multiple polymorphic class I loci linked, so far as yet known, to a single class II B locus. This architecture is very different from that of the anuran amphibian Xenopus. The number of class I loci in the axolotl can vary from 6 to 21...

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Bibliographic Details
Published in:European journal of immunology 1999-09, Vol.29 (9), p.2897-2907
Main Authors: Sammut, Bénédicte, Du Pasquier, Louis, Ducoroy, Patrick, Laurens, Véronique, Marcuz, Anne, Tournefier, Annick
Format: Article
Language:English
Subjects:
Ambystoma - genetics
Ambystoma - immunology
Ambystoma mexicanum
Amino Acid Sequence
Animals
Blotting, Southern
Conserved Sequence
Evolution
Evolution, Molecular
Genes, MHC Class I - immunology
Genes, MHC Class II - immunology
HLA-A2 Antigen - chemistry
Humans
Immune system
Major Histocompatibility Complex - genetics
Major Histocompatibility Complex - immunology
MHC class I/class II gene
Molecular Sequence Data
Polymorphism, Genetic - immunology
Protein Conformation
Urodele amphibian
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Summary:The MHC of the urodele amphibian Ambystoma mexicanum consists of multiple polymorphic class I loci linked, so far as yet known, to a single class II B locus. This architecture is very different from that of the anuran amphibian Xenopus. The number of class I loci in the axolotl can vary from 6 to 21 according to the haplotypes as shown by cDNA analysis and Southern blot studies in families. These loci can be classified into seven sequence groups with features ranging from the class Ia to the class Ib type. All individuals express genes from at least three of the seven groups, and all individuals possess the class Ia‐like type.
ISSN:0014-2980
1521-4141
DOI:10.1002/(SICI)1521-4141(199909)29:09<2897::AID-IMMU2897>3.0.CO;2-2