Tests of potential adipokinetic hormone precursor related peptide (APRP) functions: Lack of responses

The adipokinetic hormone (AKH) precursor related peptides (APRPs) are end products of the synthesis of the well‐conserved AKHs. The large amount of metabolic energy devoted to APRP synthesis suggests they have an important function(s) in the insects. Several functions have been proposed, but current...

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Bibliographic Details
Published in:Archives of insect biochemistry and physiology 1999-10, Vol.42 (2), p.163-166
Main Authors: Hatle, John D., Spring, Jeffrey H.
Format: Article
Language:English
Subjects:
adipokinetic hormone
Animals
Chromatography, High Pressure Liquid
diuresis
Grasshoppers - physiology
hyperlipemia
hypertrehalosemia
Insect Hormones - physiology
Lipid Metabolism
lubber
myotropia
phosphorylase
Phosphorylases - metabolism
Romalea microptera
Romaleidae
Trehalose - metabolism
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Summary:The adipokinetic hormone (AKH) precursor related peptides (APRPs) are end products of the synthesis of the well‐conserved AKHs. The large amount of metabolic energy devoted to APRP synthesis suggests they have an important function(s) in the insects. Several functions have been proposed, but currently none are known. We tested whether the APRPs stimulate hyperlipemia, hypertrehalosemia, fat body glycogen phosphorylase activation, Malpighian tubule secretion, and hindgut myotropia. Surprisingly, none of these responses were stimulated by APRPs isolated from the lubber grasshopper, Romalea microptera (= guttata). In addition, the APRPs delivered in concert with AKHs did not significantly increase hyperlipemia, hypertrehalosemia, or phosphorylase activation over the AKHs alone. Our data discount several proposed functions for the APRPs. Arch. Insect Biochem. Physiol. 42:163–166,1999. © 1999 Wiley‐Liss, Inc.
ISSN:0739-4462
1520-6327
DOI:10.1002/(SICI)1520-6327(199910)42:2<163::AID-ARCH6>3.0.CO;2-S