Middle ear adenomatous tumor with a predominant neuroendocrine component

A primary adenomatous tumor of the middle ear was examined by light microscopy, ultrastructural and immunohistochemical techniques. In support of its extensive neuroendocrine differentiation, was the diffuse detection of neuron-specific enolase (NSE) and positive immunoreaction with antibodies to ch...

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Bibliographic Details
Published in:Pathology 1999, Vol.31 (3), p.284-287
Main Authors: Paraskevakou, Helen, Lazaris, Andreas Ch, Kandiloros, Dimitrios Ch, Papadimitriou, Konstandina, Adamopoulos, Georgios, Davaris, Panayiotis S.
Format: Article
Language:English
Subjects:
Adenoma - enzymology
Adenoma - metabolism
Adenoma - pathology
Adenoma - ultrastructure
Adult
Biological and medical sciences
Chromogranins - metabolism
Cytoplasmic Granules - ultrastructure
Ear Neoplasms - enzymology
Ear Neoplasms - metabolism
Ear Neoplasms - pathology
Ear Neoplasms - ultrastructure
Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology
Ear, Middle - pathology
Ear, Middle - ultrastructure
electron microscopy
Humans
Immunohistochemistry
Male
Medical sciences
Microscopy, Electron
Middle ear adenoma
neuroendocrine differentiation
Neuroendocrine Tumors - enzymology
Neuroendocrine Tumors - metabolism
Neuroendocrine Tumors - pathology
Neuroendocrine Tumors - ultrastructure
Otorhinolaryngology. Stomatology
Phosphopyruvate Hydratase - biosynthesis
Synaptophysin - metabolism
Tumors
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Description
Summary:A primary adenomatous tumor of the middle ear was examined by light microscopy, ultrastructural and immunohistochemical techniques. In support of its extensive neuroendocrine differentiation, was the diffuse detection of neuron-specific enolase (NSE) and positive immunoreaction with antibodies to chromogranin and synaptophysin. The great majority of tumor cells contained neurosecretory granules and intraluminal mucin production could be focally detected. These characteristics confirm the diagnosis of a middle ear adenomatous tumor (MEAT) of a biphasic nature and with a prominent neuroendocrine component.
ISSN:0031-3025
1465-3931
DOI:10.1080/003130299105179