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Middle ear adenomatous tumor with a predominant neuroendocrine component

A primary adenomatous tumor of the middle ear was examined by light microscopy, ultrastructural and immunohistochemical techniques. In support of its extensive neuroendocrine differentiation, was the diffuse detection of neuron-specific enolase (NSE) and positive immunoreaction with antibodies to ch...

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Published in:	Pathology 1999, Vol.31 (3), p.284-287
Main Authors:	Paraskevakou, Helen, Lazaris, Andreas Ch, Kandiloros, Dimitrios Ch, Papadimitriou, Konstandina, Adamopoulos, Georgios, Davaris, Panayiotis S.
Format:	Article
Language:	English
Subjects:	Adenoma - enzymology Adenoma - metabolism Adenoma - pathology Adenoma - ultrastructure Adult Biological and medical sciences Chromogranins - metabolism Cytoplasmic Granules - ultrastructure Ear Neoplasms - enzymology Ear Neoplasms - metabolism Ear Neoplasms - pathology Ear Neoplasms - ultrastructure Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology Ear, Middle - pathology Ear, Middle - ultrastructure electron microscopy Humans Immunohistochemistry Male Medical sciences Microscopy, Electron Middle ear adenoma neuroendocrine differentiation Neuroendocrine Tumors - enzymology Neuroendocrine Tumors - metabolism Neuroendocrine Tumors - pathology Neuroendocrine Tumors - ultrastructure Otorhinolaryngology. Stomatology Phosphopyruvate Hydratase - biosynthesis Synaptophysin - metabolism Tumors
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creator	Paraskevakou, Helen Lazaris, Andreas Ch Kandiloros, Dimitrios Ch Papadimitriou, Konstandina Adamopoulos, Georgios Davaris, Panayiotis S.
description	A primary adenomatous tumor of the middle ear was examined by light microscopy, ultrastructural and immunohistochemical techniques. In support of its extensive neuroendocrine differentiation, was the diffuse detection of neuron-specific enolase (NSE) and positive immunoreaction with antibodies to chromogranin and synaptophysin. The great majority of tumor cells contained neurosecretory granules and intraluminal mucin production could be focally detected. These characteristics confirm the diagnosis of a middle ear adenomatous tumor (MEAT) of a biphasic nature and with a prominent neuroendocrine component.
doi_str_mv	10.1080/003130299105179
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Stomatology ; Phosphopyruvate Hydratase - biosynthesis ; Synaptophysin - metabolism ; Tumors</subject><ispartof>Pathology, 1999, Vol.31 (3), p.284-287</ispartof><rights>1999 Royal College of Pathologists of Australasia</rights><rights>1999 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1999</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-d2fb1f1c0957804258a4eeeea38aa9b4bc9eb7bde9e687d7bc00bd94c45a41523</citedby><cites>FETCH-LOGICAL-c422t-d2fb1f1c0957804258a4eeeea38aa9b4bc9eb7bde9e687d7bc00bd94c45a41523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4022,27921,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1922836$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10503278$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Paraskevakou, Helen</creatorcontrib><creatorcontrib>Lazaris, Andreas Ch</creatorcontrib><creatorcontrib>Kandiloros, Dimitrios Ch</creatorcontrib><creatorcontrib>Papadimitriou, Konstandina</creatorcontrib><creatorcontrib>Adamopoulos, Georgios</creatorcontrib><creatorcontrib>Davaris, Panayiotis S.</creatorcontrib><title>Middle ear adenomatous tumor with a predominant neuroendocrine component</title><title>Pathology</title><addtitle>Pathology</addtitle><description>A primary adenomatous tumor of the middle ear was examined by light microscopy, ultrastructural and immunohistochemical techniques. In support of its extensive neuroendocrine differentiation, was the diffuse detection of neuron-specific enolase (NSE) and positive immunoreaction with antibodies to chromogranin and synaptophysin. The great majority of tumor cells contained neurosecretory granules and intraluminal mucin production could be focally detected. 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Stomatology</subject><subject>Phosphopyruvate Hydratase - biosynthesis</subject><subject>Synaptophysin - metabolism</subject><subject>Tumors</subject><issn>0031-3025</issn><issn>1465-3931</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNp9kEGLFDEQRoMo7rh69iZ9EG_tVtLpSXKUZXWFFS96DtVJNZOlOxmTtOK_N8sMKILWpQ71vo_iMfaSw1sOGq4ABj6AMIbDyJV5xHZc7sd-MAN_zHYP176dxwv2rJR7AJBa66fsotEwCKV37PZT8H6hjjB36CmmFWvaSle3NeXuR6iHDrtjJp_WEDHWLtKWE0WfXA6ROpfWY4oU63P2ZMal0IvzvmRf3998ub7t7z5_-Hj97q53UojaezFPfOYOzKg0SDFqlNQGB41oJjk5Q5OaPBnaa-XV5AAmb6STI0o-iuGSvTn1HnP6tlGpdg3F0bJgpPa4VaC0UsI08OoEupxKyTTbYw4r5p-Wg32QZ_-S1xKvztXbtJL_gz_ZasDrM4DF4TJnjC6U35wRQg_7hpkTFuKc8ooHwqUeHGay92nLsen5zw_nLDWH3wNlW1yg6MiHTK5an8I_s78A1RabYA</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>Paraskevakou, Helen</creator><creator>Lazaris, Andreas Ch</creator><creator>Kandiloros, Dimitrios Ch</creator><creator>Papadimitriou, Konstandina</creator><creator>Adamopoulos, Georgios</creator><creator>Davaris, Panayiotis S.</creator><general>Elsevier B.V</general><general>Informa UK Ltd</general><general>Taylor and Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1999</creationdate><title>Middle ear adenomatous tumor with a predominant neuroendocrine component</title><author>Paraskevakou, Helen ; Lazaris, Andreas Ch ; Kandiloros, Dimitrios Ch ; Papadimitriou, Konstandina ; Adamopoulos, Georgios ; Davaris, Panayiotis S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-d2fb1f1c0957804258a4eeeea38aa9b4bc9eb7bde9e687d7bc00bd94c45a41523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adenoma - enzymology</topic><topic>Adenoma - metabolism</topic><topic>Adenoma - pathology</topic><topic>Adenoma - ultrastructure</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Chromogranins - metabolism</topic><topic>Cytoplasmic Granules - ultrastructure</topic><topic>Ear Neoplasms - enzymology</topic><topic>Ear Neoplasms - metabolism</topic><topic>Ear Neoplasms - pathology</topic><topic>Ear Neoplasms - ultrastructure</topic><topic>Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology</topic><topic>Ear, Middle - pathology</topic><topic>Ear, Middle - ultrastructure</topic><topic>electron microscopy</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>Middle ear adenoma</topic><topic>neuroendocrine differentiation</topic><topic>Neuroendocrine Tumors - enzymology</topic><topic>Neuroendocrine Tumors - metabolism</topic><topic>Neuroendocrine Tumors - pathology</topic><topic>Neuroendocrine Tumors - ultrastructure</topic><topic>Otorhinolaryngology. 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subjects	Adenoma - enzymology Adenoma - metabolism Adenoma - pathology Adenoma - ultrastructure Adult Biological and medical sciences Chromogranins - metabolism Cytoplasmic Granules - ultrastructure Ear Neoplasms - enzymology Ear Neoplasms - metabolism Ear Neoplasms - pathology Ear Neoplasms - ultrastructure Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology Ear, Middle - pathology Ear, Middle - ultrastructure electron microscopy Humans Immunohistochemistry Male Medical sciences Microscopy, Electron Middle ear adenoma neuroendocrine differentiation Neuroendocrine Tumors - enzymology Neuroendocrine Tumors - metabolism Neuroendocrine Tumors - pathology Neuroendocrine Tumors - ultrastructure Otorhinolaryngology. Stomatology Phosphopyruvate Hydratase - biosynthesis Synaptophysin - metabolism Tumors
title	Middle ear adenomatous tumor with a predominant neuroendocrine component
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