Membranous glomerulonephritis induced in the pig by antibody to angiotensin-converting enzyme : Considerations on its relevance to the pathogenesis of human idiopathic membranous glomerulonephritis

In the course of studies on the humoral consequences of swine to primate xenotransplantation, the investigators induced formation of glomerular subepithelial immune deposits and tubular lesions in pigs injected with heterologous antibody to angiotensin-converting enzyme. This study describes the mor...

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Bibliographic Details
Published in:Journal of the American Society of Nephrology 1999-10, Vol.10 (10), p.2102-2108
Main Authors: MARUYAMA, S, CANTU, E. III, DEMARTINO, C, VLADUTIU, A, CALDWELL, P. R. B, WANG, C. Y, D'AGATI, V, GODMAN, G, STERN, D. M, ANDRES, G
Format: Article
Language:English
Subjects:
Animals
Antibodies - analysis
Antibodies - immunology
Antigen-Antibody Reactions
Biological and medical sciences
Cells, Cultured
Disease Models, Animal
Endothelium - chemistry
Epithelium - chemistry
Glomerulonephritis
Glomerulonephritis, Membranous - enzymology
Glomerulonephritis, Membranous - immunology
Glomerulonephritis, Membranous - pathology
Haplorhini
Humans
Immunoglobulin G - analysis
Immunohistochemistry
Kidney Glomerulus - immunology
Kidney Glomerulus - pathology
Medical sciences
Mice
Microscopy, Confocal
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Peptidyl-Dipeptidase A - immunology
Rabbits
Radioimmunoassay
Rats
Sensitivity and Specificity
Serum Albumin, Bovine - immunology
Species Specificity
Swine
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Description
Summary:In the course of studies on the humoral consequences of swine to primate xenotransplantation, the investigators induced formation of glomerular subepithelial immune deposits and tubular lesions in pigs injected with heterologous antibody to angiotensin-converting enzyme. This study describes the morphology of the lesions, discusses their mechanism, explains their relevance for understanding the pathogenesis of human idiopathic membranous glomerulonephritis, and proposes future directions for investigations.
ISSN:1046-6673
1533-3450
DOI:10.1681/ASN.V10102102