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Enhanced anti-cancer activities of some derivatives of titanocene dichloride
The compounds ( η 5-C 5H 5) 2TiCl 2 ( I), currently undergoing phase II trials, ( η 5-C 5H 5)( η 5-C 5H 4CO 2Me)TiCl 2 ( II) and ( η 5-C 5H 4CO 2Me) 2TiCl 2 ( III) are assessed for their efficacies against a small lung cancer cell line. It is found that the introduction of the electron withdrawing c...
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| Published in: | Journal of inorganic biochemistry 2001-03, Vol.84 (1), p.159-162 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c427t-79f28adb4be8e4c8aee327c01575c9f0197dd02dfd062904db02137ed3c5da783 |
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| container_end_page | 162 |
| container_issue | 1 |
| container_start_page | 159 |
| container_title | Journal of inorganic biochemistry |
| container_volume | 84 |
| creator | Boyles, John R. Baird, Michael C. Campling, Barbara G. Jain, Nidhi |
| description | The compounds (
η
5-C
5H
5)
2TiCl
2 (
I), currently undergoing phase II trials, (
η
5-C
5H
5)(
η
5-C
5H
4CO
2Me)TiCl
2 (
II) and (
η
5-C
5H
4CO
2Me)
2TiCl
2 (
III) are assessed for their efficacies against a small lung cancer cell line. It is found that the introduction of the electron withdrawing carbomethoxy group into the cyclopentadienyl rings increases the effectiveness of this class of drugs, such that
III compares favorably with the well known cisplatin. |
| doi_str_mv | 10.1016/S0162-0134(00)00203-8 |
| format | article |
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η
5-C
5H
5)
2TiCl
2 (
I), currently undergoing phase II trials, (
η
5-C
5H
5)(
η
5-C
5H
4CO
2Me)TiCl
2 (
II) and (
η
5-C
5H
4CO
2Me)
2TiCl
2 (
III) are assessed for their efficacies against a small lung cancer cell line. It is found that the introduction of the electron withdrawing carbomethoxy group into the cyclopentadienyl rings increases the effectiveness of this class of drugs, such that
III compares favorably with the well known cisplatin.</description><identifier>ISSN: 0162-0134</identifier><identifier>EISSN: 1873-3344</identifier><identifier>DOI: 10.1016/S0162-0134(00)00203-8</identifier><identifier>PMID: 11330477</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Anti-cancer drugs ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Carcinoma, Small Cell - drug therapy ; Humans ; Lung Neoplasms - drug therapy ; Metallocenes ; Organometallic Compounds - chemistry ; Organometallic Compounds - pharmacology ; Titanocene dichloride ; Tumor Cells, Cultured</subject><ispartof>Journal of inorganic biochemistry, 2001-03, Vol.84 (1), p.159-162</ispartof><rights>2001 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-79f28adb4be8e4c8aee327c01575c9f0197dd02dfd062904db02137ed3c5da783</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11330477$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boyles, John R.</creatorcontrib><creatorcontrib>Baird, Michael C.</creatorcontrib><creatorcontrib>Campling, Barbara G.</creatorcontrib><creatorcontrib>Jain, Nidhi</creatorcontrib><title>Enhanced anti-cancer activities of some derivatives of titanocene dichloride</title><title>Journal of inorganic biochemistry</title><addtitle>J Inorg Biochem</addtitle><description>The compounds (
η
5-C
5H
5)
2TiCl
2 (
I), currently undergoing phase II trials, (
η
5-C
5H
5)(
η
5-C
5H
4CO
2Me)TiCl
2 (
II) and (
η
5-C
5H
4CO
2Me)
2TiCl
2 (
III) are assessed for their efficacies against a small lung cancer cell line. It is found that the introduction of the electron withdrawing carbomethoxy group into the cyclopentadienyl rings increases the effectiveness of this class of drugs, such that
III compares favorably with the well known cisplatin.</description><subject>Anti-cancer drugs</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Carcinoma, Small Cell - drug therapy</subject><subject>Humans</subject><subject>Lung Neoplasms - drug therapy</subject><subject>Metallocenes</subject><subject>Organometallic Compounds - chemistry</subject><subject>Organometallic Compounds - pharmacology</subject><subject>Titanocene dichloride</subject><subject>Tumor Cells, Cultured</subject><issn>0162-0134</issn><issn>1873-3344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNqFkE1LAzEQhoMotlZ_grIn0cPq5GOb3ZNIqR9Q8KCeQzaZpZH90CQt-O_d7RY9esmEmSfzkoeQcwo3FOj89rU_WAqUiyuAawAGPM0PyJTmkqecC3FIpr_IhJyE8AEAWSbkMZlQyjkIKadktWzXujVoE91Gl5rh7hNtotu66DAkXZWErsHEondb3bfHXnRRt53Btp84s6477yyekqNK1wHP9nVG3h-Wb4undPXy-Ly4X6VGMBlTWVQs17YUJeYoTK4ROZMGaCYzU1RAC2ktMFtZmLMChC2BUS7RcpNZLXM-I5fj3k_ffW0wRNW4YLCudYvdJigJsgAJrAezETS-C8FjpT69a7T_VhTUoFHtNKrBkQJQO41qCLjYB2zKBu3fq723HrgbAey_uXXoVTAOB4_Oo4nKdu6fiB-JXYIn</recordid><startdate>20010301</startdate><enddate>20010301</enddate><creator>Boyles, John R.</creator><creator>Baird, Michael C.</creator><creator>Campling, Barbara G.</creator><creator>Jain, Nidhi</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010301</creationdate><title>Enhanced anti-cancer activities of some derivatives of titanocene dichloride</title><author>Boyles, John R. ; Baird, Michael C. ; Campling, Barbara G. ; Jain, Nidhi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-79f28adb4be8e4c8aee327c01575c9f0197dd02dfd062904db02137ed3c5da783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Anti-cancer drugs</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Carcinoma, Small Cell - drug therapy</topic><topic>Humans</topic><topic>Lung Neoplasms - drug therapy</topic><topic>Metallocenes</topic><topic>Organometallic Compounds - chemistry</topic><topic>Organometallic Compounds - pharmacology</topic><topic>Titanocene dichloride</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boyles, John R.</creatorcontrib><creatorcontrib>Baird, Michael C.</creatorcontrib><creatorcontrib>Campling, Barbara G.</creatorcontrib><creatorcontrib>Jain, Nidhi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of inorganic biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boyles, John R.</au><au>Baird, Michael C.</au><au>Campling, Barbara G.</au><au>Jain, Nidhi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhanced anti-cancer activities of some derivatives of titanocene dichloride</atitle><jtitle>Journal of inorganic biochemistry</jtitle><addtitle>J Inorg Biochem</addtitle><date>2001-03-01</date><risdate>2001</risdate><volume>84</volume><issue>1</issue><spage>159</spage><epage>162</epage><pages>159-162</pages><issn>0162-0134</issn><eissn>1873-3344</eissn><abstract>The compounds (
η
5-C
5H
5)
2TiCl
2 (
I), currently undergoing phase II trials, (
η
5-C
5H
5)(
η
5-C
5H
4CO
2Me)TiCl
2 (
II) and (
η
5-C
5H
4CO
2Me)
2TiCl
2 (
III) are assessed for their efficacies against a small lung cancer cell line. It is found that the introduction of the electron withdrawing carbomethoxy group into the cyclopentadienyl rings increases the effectiveness of this class of drugs, such that
III compares favorably with the well known cisplatin.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>11330477</pmid><doi>10.1016/S0162-0134(00)00203-8</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0162-0134 |
| ispartof | Journal of inorganic biochemistry, 2001-03, Vol.84 (1), p.159-162 |
| issn | 0162-0134 1873-3344 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70790702 |
| source | ScienceDirect Journals |
| subjects | Anti-cancer drugs Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Carcinoma, Small Cell - drug therapy Humans Lung Neoplasms - drug therapy Metallocenes Organometallic Compounds - chemistry Organometallic Compounds - pharmacology Titanocene dichloride Tumor Cells, Cultured |
| title | Enhanced anti-cancer activities of some derivatives of titanocene dichloride |
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