Differential expression of the subunits of the glucose-6-phosphatase system in the clear cell type of human renal cell carcinoma – no evidence for an overexpression of protein kinase B

The expression of two components of the glucose-6-phosphatase system, the catalytic subunit (G6PaseC) and the glucose-6-phosphate transporter, was analyzed in the clear cell type of human renal cell carcinoma. The expression of G6PaseC was decreased in tumours compared with non-tumourous tissue of t...

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Bibliographic Details
Published in:Cancer letters 2001-06, Vol.167 (1), p.85-90
Main Authors: Schmoll, Dieter, Balabanov, Stefan, Schwarck, Doreen, Burchell, Ann, Kleist, Britta, Zimmermann, Uwe, Walther, Reinhard
Format: Article
Language:English
Subjects:
Aged
Akt
Antiporters - biosynthesis
Antiporters - genetics
Biological and medical sciences
Blotting, Northern
Carcinoma, Renal Cell - enzymology
Carcinoma, Renal Cell - genetics
Catalytic Domain - genetics
Clear cell
Down-Regulation - physiology
Female
Gene Expression Regulation, Enzymologic - physiology
Gene Expression Regulation, Neoplastic - physiology
Glucose-6-phosphatase
Glucose-6-Phosphatase - antagonists & inhibitors
Glucose-6-Phosphatase - biosynthesis
Glucose-6-Phosphatase - genetics
Humans
Kidney Neoplasms - enzymology
Kidney Neoplasms - genetics
Kidneys
Male
Medical sciences
Middle Aged
Monosaccharide Transport Proteins - biosynthesis
Monosaccharide Transport Proteins - genetics
Nephrology. Urinary tract diseases
Protein kinase B
Protein-Serine-Threonine Kinases
Proto-Oncogene Proteins - biosynthesis
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins c-akt
Renal cell carcinoma
Reverse Transcriptase Polymerase Chain Reaction
Tumors of the urinary system
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Summary:The expression of two components of the glucose-6-phosphatase system, the catalytic subunit (G6PaseC) and the glucose-6-phosphate transporter, was analyzed in the clear cell type of human renal cell carcinoma. The expression of G6PaseC was decreased in tumours compared with non-tumourous tissue of the same patient. The expression of G6PaseT varied with no general trend between tumours and control tissue. The expression of protein kinase B (PKB) was unchanged in the tumours, suggesting that the down-regulation of G6PaseC in clear cells and the maintenance of the transformed phenotype are not predominantly caused by an overexpression of PKB.
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(01)00465-7