beta(2)-microglobulin kinetics in nocturnal haemodialysis

• Published in: Nephrology, dialysis, transplantation dialysis, transplantation, 2000-01, Vol.15 (1), p.58-64
• Main Authors: Raj, D S, Ouwendyk, M, Francoeur, R, Pierratos, A
• Format: Article
• Language: English
• Subjects: Adult; Amyloidosis - blood; Amyloidosis - etiology; Amyloidosis - prevention & control; beta 2-Microglobulin - blood; Cross-Over Studies; Female; Humans; Kidney Failure, Chronic - blood; Kidney Failure, Chronic - therapy; Kinetics; Male; Middle Aged; Renal Dialysis - adverse effects; Renal Dialysis - methods; Time Factors
• ISSN: 0931-0509
• DOI: 10.1093/ndt/15.1.58

beta(2)-Microglobulin (beta(2)m) is a major component of dialysis-related amyloidosis. The available therapeutic options do not permit normalization of the serum beta(2)m level. In a cross-over trial, we studied the kinetics of beta(2)m during two different dialytic techniques. Ten stable, anuric end-stage renal disease patients were studied during two consecutive weeks of three conventional (CHD) and six nocturnal haemodialysis (NHD) sessions. CHD was performed for 4 h three times weekly using a polysulfone dialyser (F80, surface area of 1.8 m(2)) with a mean blood and dialysate flow rate of 401+/-91.6 and 514+/-10.9 ml/min, respectively. The NHD was done with a smaller dialyser (F40, surface area of 0.7 m(2)) and lower blood (281+/-17 ml/min) and dialysate flow rates (99+/-1.2 ml/min) for 8 h, six nights a week. Weekly removal of urea (51.6+/-24.6 vs 43.1+/-20.5 g) and creatinine (8501+/-5204 vs 6319+/-4134 mg) were comparable with the two modalities of dialysis but the mass of beta(2)m removed was significantly higher with NHD (127+/-48 vs 585+/-309 mg, P